Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery

被引：0
|
作者：
Hulde, Nikolai [1 ]
Zittermann, Armin [2 ]
Deutsch, Marcus-Andre [2 ]
Gummert, Jan F. [2 ]
von Dossow, Vera [1 ]
Koster, Andreas [1 ]
机构：
[1] Herz & Diabeteszentrum Nordrhein Westfalen, Inst Anesthesiol & Pain Therapy, Bad Oeynhausen, Nordrhein Westf, Germany
[2] Herz & Diabeteszentrum Nordrhein Westfalen, Clin Thorac & Cardiovasc Surg, Georgstr 11, D-32545 Bad Oeynhausen, Nordrhein Westf, Germany
来源：
THORACIC AND CARDIOVASCULAR SURGEON | 2024年 / 72卷 / 01期
关键词：
delirium; tranexamic acid; renal impairment;
D O I：
10.1055/s-0042-1745811
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated whether in patients undergoing off-pump coronary artery bypass grafting surgery a single bolus of 1 g tranexamic acid (TXA) impacts the risk of postoperative delirium using the propensity score matching approach. In 2,757 pairs, the risk of delirium was 4.2% (TXA group) and 5.0% (non-TXA group), with a relative risk in the TXA versus the non-TXA group of 0.83 (95% confidence interval: 0.65-1.07; p = 0.16). There was no significant interaction between TXA administration and renal function on the risk of delirium ( p = 0.12). Data indicate that a single bolus of 1 g TXA does not increase the risk of delirium in patients undergoing off-pump surgery.
引用
收藏
页码：51 / 54
页数：4
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