TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

被引：0

作者：

Zheng, Jiecheng ^{[1
]}

Zhu, Dali ^{[1
]}

Yang, Zhangyou ^{[1
]}

Chen, Huali ^{[1
]}

Wang, Wei ^{[2
]}

Gan, Lin Ling ^{[3
]}

Gan, Zongjie ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China

[2] Chongqing Fuling Inst Food & Drug Control, Chongqing 408102, Peoples R China

[3] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Sch Pharm, Chongqing 401331, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2023年 / 55卷 / 09期

基金：

中国国家自然科学基金;

关键词：

metal-free; TBHP/KI; 2-acyloxazole; oxidative cyclization; 2,5-DISUBSTITUTED OXAZOLES; EFFICIENT PREPARATION; METHYL KETONES; IMIDAZOLES; DISCOVERY; IODINE;

D O I：

10.1055/a-1996-8388

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free and facile synthesis of substituted 2-acyloxazole derivatives from alpha-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.

引用

页码：1419 / 1426

页数：8

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