Enhancement of antibacterial and anticancer properties lanthanum insight into zinc oxide nanoparticles prepared via coprecipitation process

The development of La-doped ZnO NPs exhibits potential to improve the biocidal properties of nanomaterials for medical applications to treat MDR bacteria and breast cancer activity. A co-precipitation process was used to make zinc oxide (ZnO) nanoparticles (NPs) and lanthanum dopedZnO (ZnLaO) NPs. XRD patterns revealed the hexagonal wurtzite structure of the ZnO and ZnLaO NPs. Zn-O stretching frequencies, ZnO, and ZnLaO were found in the FTIR spectra at 486 and 556 cm-1, respectively. SEM and EDAX spectra validated the shape and chemical composition of ZnO and ZnLaO NPs. Based on UV-Vis spectroscopic measurements, the excitonic peaks for the two samples were found to be about 367 nm and 364 nm, respectively. The PL experiments were con-ducted at room temperature, and green emission peaks were observed in the visible range for ZnO and ZnLaO NPs at 522 and 525 nm, respectively. ZnO and ZnLaO NPs were examined for antibacterial activity against gram -positive bacteria (S. aureus and B. subtilis) and gram-negative bacteria (E. coli and K. pneumonia) bacterial strains. The ZnLaO NPs potential antibacterial activity was higher than that of ZnO NPs alone, and increasing the concentration of ZnLaO NPs also increased the antibacterial activity. Furthermore, the ZnO and ZnLaO NPs were treated with human breast cancer (MCF-7) cell lines. The ZnLaO NPs exhibit more anticancer activity at a minimum concentration. As a result of these investigations, theZnLaO NPs can make antibacterial and anticancer agents and those employed in biomedical applications.