CUSP06/AMT-707, a new CDH6-targeting antibody-drug conjugate, demonstrates potent antitumor activity in preclinical models

被引:0
|
作者
Lu, Wei
Shi, Jing
Liu, Shu-Hui
Covino, Nicole
Meng, Xun
Slosberg, Eric D.
机构
关键词
D O I
10.1158/1538-7445.AM2023-6320
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6320
引用
收藏
页数:2
相关论文
共 50 条
  • [1] DS-6000a, a novel CDH6-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd, demonstrates potent antitumor activity in preclinical models
    Suzuki, H.
    Nagase, S.
    Saito, C.
    Nagata, M.
    Kaneda, Y.
    Honda, K.
    Nishiya, Y.
    Honda, T.
    Nakada, T.
    Goto, R.
    Ishizaka, T.
    Myobatake, Y.
    Abe, Y.
    Agatsuma, T.
    ANNALS OF ONCOLOGY, 2021, 32 : S363 - S364
  • [2] Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma
    Tu, Jianghua
    Toh, Yukimatsu
    Aldana, Adela M.
    Wen, Jake J.
    Wu, Ling
    Jacob, Joan
    Li, Li
    Pan, Sheng
    Carmon, Kendra S.
    Liu, Qingyun J.
    PHARMACEUTICS, 2024, 16 (07)
  • [3] An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer
    Jacob, Joan
    Francisco, Liezl E.
    Chatterjee, Treena
    Liang, Zhengdong
    Subramanian, Shraddha
    Liu, Qingyun J.
    Rowe, Julie H.
    Carmon, Kendra S.
    BRITISH JOURNAL OF CANCER, 2023, 128 (08) : 1592 - 1602
  • [4] DS-1062a, a novel TROP2-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd, demonstrates potent antitumor activity in preclinical models
    Okajima, Daisuke
    Yamaguchi, Junko
    Kitamura, Michiko
    Kamei, Reiko
    Maejima, Takanori
    Shibutani, Tomoko
    Yasuda, Satoru
    Toki, Tadashi
    Karibe, Tsuyoshi
    Fujitani, Tomomichi
    Nakada, Takashi
    Goto, Riki
    Noguchi, Yutaka
    Abe, Yuki
    Agatsuma, Toshinori
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [5] Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models
    Suzuki, Hirokazu
    Nagase, Shotaro
    Saito, Chiemi
    Takatsuka, Atsuko
    Nagata, Motoko
    Honda, Kokichi
    Kaneda, Yuki
    Nishiya, Yumi
    Honda, Tomoyo
    Ishizaka, Tomomichi
    Nakamura, Kensuke
    Nakada, Takashi
    Abe, Yuki
    Agatsuma, Toshinori
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (03) : 257 - 271
  • [6] Antitumor activity of Antibody-Drug Conjugates targeting cancer-expressed EGFR in Preclinical Models
    Fitzgerald, D.
    Ho, E. C. H.
    Miller, E.
    Qiu, R.
    Antignani, A.
    EUROPEAN JOURNAL OF CANCER, 2022, 174 : S86 - S87
  • [7] A Phase 1 Study of a CDH6-Targeting Antibody-Drug Conjugate in Patients with Advanced Solid Tumors with Evaluation of Inflammatory and Neurological Adverse Events
    Schoffski, Patrick
    Concin, Nicole
    Suarez, Cristina
    Subbiah, Vivek
    Ando, Yuichi
    Ruan, Shiling
    Wagner, Joel P.
    Mansfield, Keith
    Zhu, Xu
    Origuchi, Shizuka
    DiDominick, Sarah
    Bialucha, Carl U.
    Faris, Jason E.
    Tran, Ben
    ONCOLOGY RESEARCH AND TREATMENT, 2021, 44 (10) : 547 - 556
  • [8] Development of a novel antibody-drug conjugate targeting endosialin/TEM-1: potent antitumor activity in sarcoma
    Sala, Gianluca
    Iacobelli, Stefano
    Capone, Emily
    PIccolo, Enza
    Sauniere, Jean-Fred
    Douet, Vanessa Vannucci
    CANCER RESEARCH, 2017, 77
  • [9] A biparatopic HER2-targeting antibody-drug conjugate demonstrates potent antitumor activity in primary tumor models that are refractory to or ineligible for HER2-targeted therapies
    Li, J. Y.
    Perry, S. R.
    Muniz-Medina, V.
    Wetzel, L. K.
    Rebelatto, M. C.
    Bezabeh, B. Z.
    Fleming, R. L.
    Dimasi, N.
    Gao, C.
    Wu, H.
    Jenkins, D. W.
    Osbourn, J. K.
    Coats, S. R.
    CANCER RESEARCH, 2016, 76
  • [10] A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity
    Synan, Alyssa
    Wu, Nila C.
    Velazquez, Roberto
    Gesner, Thomas
    Logel, Claude
    Mueller, Kathrin
    Green, Andrew
    Barzaghi-Rinaudo, Patrizia
    Simmons, Quincey
    Mercan, Samuele
    Shi, Xingyi
    Li, Xun
    Sagar, Vivek
    Korn, Joshua
    Mclaughlin, Margaret
    Tschantz, William R.
    Hainzl, Dominik
    Malamas, Anthony
    Huber, Thomas
    Cebe, Regis
    Xie, Kathleen T.
    D'Alessio, Joseph A.
    MABS, 2025, 17 (01)