Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms

被引：5

作者：

Dana, Seyyed Mohammad Matin Alavi ^{[1
]}

Farkhondeh, Tahereh ^{[2
]}

Aschner, Michael ^{[3
]}

Darroudi, Majid ^{[4
]}

Samini, Helia ^{[5
]}

Samarghandian, Saeed ^{[6
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[2] Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran

[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Forchheimer 2091300 Morris Pk Ave, Bronx, NY USA

[4] Neyshabur Univ Med Sci, Dept Basic Sci, Neyshabur, Iran

[5] Mashhad Med Univ, Mashhad, Iran

[6] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran

来源：

CURRENT MOLECULAR PHARMACOLOGY | 2023年 / 16卷 / 07期

关键词：

Chrysin; 5; 7-dihydroxy-flavone; gastric cancer; molecular mechanisms; mechanisms of action; signaling pathway; DERIVATIVES; PROGRESSION; EXPRESSION; VIRUS; CELLS;

D O I：

10.2174/1874467216666230103105725

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

引用

页码：707 / 711

页数：5

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