Should Biologics Be Used Before Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease?

被引：1
|
作者：
Laidlaw, Tanya M. [1 ,3 ]
White, Andrew A. [2 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Div Allergy & Clin Immunol, Boston, MA USA
[2] Scripps Clin, Div Allergy Asthma & Immunol, San Diego, CA USA
[3] Brigham & Womens Hosp, Dept Med, Div Allergy & Clin Immunol, 60 Fenwood Rd, Boston, MA 02114 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2024年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Chronic rhinosinusitis; CRSwNP; Nasal polyps; Aspirin-exacerbated respiratory disease; AERD; Aspirin desen- sitization; Dupilumab; Omalizumab; Mepolizumab; Benralizumab; ENDOSCOPIC SINUS SURGERY; CHRONIC RHINOSINUSITIS; NASAL POLYPOSIS; TOLERANCE; DUPILUMAB; EFFICACY; OUTCOMES; MEPOLIZUMAB; MANAGEMENT; SAFETY;
D O I：
10.1016/j.jaip.2023.09.019
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
There has been a paradigm shift in the management of aspirinexacerbated respiratory disease (AERD). It started in 2015 when the first biologic was Food and Drug Administration (FDA) approved for severe eosinophilic asthma. Thus, there emerged a new era in the treatment of patients with type 2emediated airway diseases. This has led to an increasing number of options for patients, undoubtably a great thing, but has left clinicians without a clear answer for how to balance the therapies that exist for AERD, what to recommend for treatment, and how to best assess the benefits and rislos of each therapy. This paper aims to explore these benefits and rislos, and to provide a roadmap for future studies. (c) 2023 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2024;12:79-84)
引用
收藏
页码：79 / 84
页数：6
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