The Emerging Role of CircRNAs in Atherosclerosis

被引：4
|
作者：
Yang, Jing [1 ]
Rong, Shuling [1 ]
机构：
[1] Shanxi Med Univ, Hosp 2, Dept Cardiovasc Med, Taiyuan 030000, Shanxi, Peoples R China
来源：
CURRENT VASCULAR PHARMACOLOGY | 2023年 / 21卷 / 01期
关键词：
Atherosclerosis; circRNAs; endothelial cells; vascular smooth muscle cells; macrophages; SMOOTH-MUSCLE-CELLS; CIRCULAR RNA; LOW-DENSITY; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; INDUCED INJURY; MIGRATION; PROLIFERATION; INFLAMMATION; TRANSCRIPTION;
D O I：
10.2174/1570161121666230106153857
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiovascular diseases (CVDs) based on atherosclerosis remain the main reason for death in Western countries and China. Cardiovascular research has demonstrated that its pathogenesis is closely associated with endothelial cell (EC) injury, the phenotypic transformation of vascular smooth muscle cells (VSMCs), and the abnormal biological behaviour of macrophages. In recent years, circular RNAs (circRNAs) have received much attention for their unique role in the pathogenesis of atherosclerosis. In this review, we discussed the mechanisms associated with ECs, VSMCs, and macrophages in atherosclerosis and summarized the role of circRNAs in atherosclerosis. This review aims to provide a basis for the prevention and treatment of atherosclerosis.
引用
收藏
页码：26 / 41
页数：16
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