The effects of identical nim gene-insertion sequence combinations on the expression of the nim genes and metronidazole resistance in Bacteroides fragilis strains

被引：1
|
作者：
Mahmood, Bakhtiyar [1 ,2 ,3 ]
Juhasz, Hajnalka [1 ,2 ]
Leitsch, David [4 ]
Soki, Jozsef [1 ,2 ]
机构：
[1] Univ Szeged, Inst Med Microbiol, Albert Szent Gyorgyi Hlth Ctr, Szeged, Hungary
[2] Univ Szeged, Sch Med, Szeged, Hungary
[3] Univ Garmian, Dept Biol, Kalar, Kurdistan Regio, Iraq
[4] Med Univ Vienna, Inst Specific Prophylaxis & Trop Med, Vienna, Austria
来源：
ANAEROBE | 2023年 / 81卷
关键词：
Antibiotic resistance; B; fragilis; Gene expression; Insertion sequence element; Metronidazole; Nim; Promoter; 5-NITROIMIDAZOLE; METABOLISM;
D O I：
10.1016/j.anaerobe.2023.102739
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this study we examined whether the same nim gene-insertion sequence (IS) element combinations give rise to the same expression levels as they harbor shared IS element-borne promoters. From our quantitative analysis, we found that the expressions of the nimB and nimE genes with their cognate IS elements were similar, but the metronidazole resistance of these strains were more diverse.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：4
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