The Impact of MicroRNAs in Neonatal Necrotizing Enterocolitis and other Inflammatory Conditions of Intestine: A Review

被引:4
|
作者
Donda, Keyur [1 ]
Bose, Tanima [2 ]
Dame, Christof [3 ]
Maheshwari, Akhil [4 ]
机构
[1] Univ S Florida, Dept Pediat Perinatol & Child Hlth, Hlth Morsani Coll Med, Tampa, FL USA
[2] Ludwig Maximilians Univ Munchen, Inst Clin Neuroimmunol, Munich, Germany
[3] Charite Univ Med Berlin, Dept Neonatol, Berlin, Germany
[4] Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21218 USA
基金
美国国家卫生研究院;
关键词
Micro RNA; necrotizing enterocolitis; neonates; genetic predisposition; spontaneous intestinal perforation; intestinal inflammation; MANNOSE-BINDING LECTIN; ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNAS; RISK-FACTOR; RAT MODEL; EXPRESSION; CELLS; TARGETS; INJURY; NOD2;
D O I
10.2174/1573396318666220117102119
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The understanding of necrotizing enterocolitis (NEC) etiopathogenesis is incomplete, contributing to the lack of early biomarkers and therapeutic options. Micro RNAs (miRNAs) are a class of RNAs that can alter gene expression and modulate various physiological and pathological processes. Several studies have been performed to evaluate the role of miRNA in the pathogenesis of NEC. In this article, we review the information on miRNAs that have been specifically identified in NEC or have been noted in other inflammatory bowel disorders that share some of the histopathological abnormalities seen frequently in NEC. This review highlights miRNAs that could be useful as early biomarkers of NEC and suggests possible approaches for future translational studies focused on these analytes. It is a novel field with potential for immense translational and clinical relevance in preventing, detecting, or treating NEC in very premature infants. Impact center dot Current information categorizes necrotizing enterocolitis (NEC) as a multifactorial disease, but microRNAs (miRNAs) may influence the risk of occurrence of NEC. center dot MiRNAs may alter the severity of the intestinal injury and the clinical outcome of NEC. center dot The literature on intestinal diseases of adults suggests additional miRNAs that have not been studied in NEC yet but share some features and deserve further exploration in human NEC, especially if affecting gut dysbiosis, intestinal perfusion, and coagulation disorders.
引用
收藏
页码:5 / 14
页数:10
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