Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota

被引：1

作者：

Gomes, Paulo Wender P. ^{[1
,2
]}

Gomes, Emilli Roberta S. ^{[3
]}

Carvalho, Alice R. V. ^{[4
,5
]}

Mannochio-Russo, Helena ^{[1
,2
]}

Leao, Tiago F. ^{[6
]}

Reis, Jose Diogo E. ^{[4
]}

de Sarges, Maria Rosilda V. ^{[4
,7
]}

Mardegan, Horrana A. ^{[4
,7
]}

Pamplona, Sonia das G. S. R. ^{[4
]}

Esilva, Consuelo Yumiko Y. ^{[4
,5
,7
]}

da Silva, Milton N. ^{[4
,8
]}

机构：

[1] Univ Calif San Diego, Collaborat Mass Spectrometry Innovat Ctr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[3] Fed Univ Para UFPA, Inst Hlth Sci, Fac Nutr FANUT, R Augusto Correa,01,Guama, BR-66075110 Belem, Brazil

[4] Fed Univ Para, Inst Exact & Nat Sci, Lab Liquid Chromatog, BR-66075110 Belem, Brazil

[5] Fed Univ Para, Inst Hlth Sci, Fac Pharm, Lab Immunol, Belem, PA, Brazil

[6] Sao Paulo State Univ, Chem Inst, Araraquara, SP, Brazil

[7] Fed Univ Para, Inst Hlth Sci, Pharmaceut Sci Postgrad Program, Belem, PA, Brazil

[8] Fed Univ Para, Inst Exact & Nat Sci, BR-66075110 Belem, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 109卷

关键词：

Barbatimao; Flavan-3-ols; LC-MS/MS; Tannins; Phytonutrition; Human gut; PROCYANIDIN DIMERS; MASS-SPECTROMETRY; POLYPHENOLS; METABOLITES; EXTRACT;

D O I：

10.1016/j.jff.2023.105801

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Stryphnodendron pulcherrimum is a plant found in the Brazilian Amazon and contains high content of catechin/ (epi)catechin (flavan-3-ol) derivatives. The polymerization of this kind of flavan-3-ol generates condensed tannins, often associated to plant-based diets and gut microbiota. Thus, the discovery of condensed tannins from plants is a valuable approach once it enhances their availability from natural sources. Herein, we described a tetrameric condensed tannin (Molecular Mass 1,170 a.m.u.) tentatively identified for the first time in the barks from S. pulcherrimum. Condensed tannins-derived (flavan-3-ols units) are likely degraded in the gut, and their degradation products such as 3-hydroxyphenylacetic acid (OPAC), 3,4-dihydroxyphenylacetic acid (DHAA), 3(3,4-dihydroxyphenyl)-propionic acid (DHPA), and 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone (DHPV) could present benefits to gut microbiome metabolism. Therefore, this observational study represents a new insight into S. pulcherrimum, its molecules, and their potential benefits to avoid different diseases and gut well-functional.

引用

页数：7