Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

被引：9

作者：

Rodrigues, Fabiola Brasil Barbosa ^{[1
,2
]}

da Silva, Rosilene ^{[1
,2
]}

dos Santos, Erika Ferreira ^{[1
,2
]}

de Brito, Mioni Thieli Figueiredo Magalhaes ^{[1
]}

da Silva, Andrea Luciana Soares ^{[1
]}

Leite, Mauro de Meira ^{[1
]}

da Costa, Flavia Povoa ^{[1
,2
]}

Viana, Maria de Nazare do Socorro de Almeida ^{[1
,2
]}

de Sarges, Kevin Matheus Lima ^{[1
,2
]}

Cantanhede, Marcos Henrique Damasceno ^{[1
,2
]}

Verissimo, Adriana de Oliveira Lameira ^{[3
]}

Carvalho, Mayara da Silva ^{[3
]}

Henriques, Daniele Freitas ^{[4
]}

da Silva, Carla Pinheiro ^{[4
]}

Costa, Igor Brasil ^{[5
]}

Nunes, Juliana Abreu Lima ^{[5
]}

Costa, Iran Barros ^{[5
]}

Viana, Giselle Maria Rachid ^{[6
]}

Queiroz, Maria Alice Freitas ^{[7
]}

Lima, Sandra Souza ^{[7
]}

Lopes, Jeferson da Costa ^{[2
,7
]}

Torres, Maria Karoliny da Silva ^{[2
,7
]}

Vallinoto, Izaura Maria Vieira Cayres ^{[2
,7
]}

Bichara, Carlos David Araujo ^{[2
,7
]}

Vallinoto, Antonio Carlos Rosario ^{[7
]}

dos Santos, Eduardo Jose Melo ^{[1
]}

机构：

[1] Univ Fed Para, Inst Ciencias Biol, Lab Genet Doencas Complexas, BR-58255000 Belem, Para, Brazil

[2] Univ Fed Para, Programa Posgrad Biol Agentes Infecciosos & Paras, BR-58255000 Belem, Brazil

[3] Hosp Adventista Belem, BR-66093681 Belem, Para, Brazil

[4] Minist Saude Brasil, Secretaria Vigilancia Saude, Secao Arbovirol & Febres Hemorrag, Inst Evandro Chagas, BR-67000000 Ananindeua, Brazil

[5] Minist Saude Brasil, Secretaria Vigilancia Saude, Inst Evandro Chagas, Lab Imunol,Secao Virol, BR-67000000 Ananindeua, Brazil

[6] Minist Saude Brasil, Secretaria Vigilancia Saude, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria,Secao Parasitol, BR-67000000 Ananindeua, Brazil

[7] Univ Fed Para, Inst Ciencias Biol, Lab Virol, BR-58255000 Belem, Para, Brazil

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 05期

关键词：

IL6; IL6R; IL6ST; COVID-19; SARS-CoV-2; INTERLEUKIN-6; CYTOKINE;

D O I：

10.3390/v15051197

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.

引用

页数：8

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