Primary headache disorders: From pathophysiology to neurostimulation therapies

被引:6
|
作者
Wang, Ziying [1 ,2 ,3 ]
Yang, Xiangyu [1 ,2 ,3 ,4 ]
Zhao, Binglei [4 ]
Li, Weidong [1 ,2 ,3 ,4 ,5 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Minist Educ, BioX Inst,Key Lab Genet Dev & Neuropsychiat Disor, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai, Peoples R China
[3] World Laureates Assoc, WLA Labs, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Global Inst Future Technol, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
Primary headache disorders; Migraine; Cluster headache; Neurostimulation; OCCIPITAL NERVE-STIMULATION; DEEP-BRAIN-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; SPHENOPALATINE GANGLION STIMULATION; CHRONIC CLUSTER HEADACHE; SPREADING DEPRESSION; CHRONIC MIGRAINE; PRIMARY MOTOR; DOUBLE-BLIND; HYPOTHALAMIC ACTIVATION;
D O I
10.1016/j.heliyon.2023.e14786
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Primary headache disorders including migraine, cluster headache, and tension-type headache are among the most common disabling diseases worldwide. The unclear pathogenesis of primary headache disorders has led to high rates of misdiagnosis and limited available treatment options. In this review, we have summarized the pathophysiological factors for a better understanding of primary headache disorders. Advances in functional neuroimaging, genetics, neurophysiology have indicated that cortical hyperexcitability, regional brain dysfunction, central sensitization and neuroplasticity changes play vital roles in the development of primary headache disorders. Moreover, we have also discussed a series of neurostimulation approaches with their stimulation mechanism, safety and efficacy for prevention and treatment of primary headache disorders. Noninvasive or implantable neurostimulation techniques show great promise for treating refractory primary headache disorders.
引用
收藏
页数:11
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