KEL1 negative red cell transfusions for females of current or future child-bearing potential: A clinical impact and feasibility study

被引：3

作者：

Ning, Shuoyan ^{[1
,2
,3
,8
]}

Morin, Pierre-Aurele ^{[5
]}

Elahie, Allahna ^{[4
]}

Li, Na ^{[2
,6
]}

Liu, Yang ^{[2
]}

Barty, Rebecca ^{[2
]}

Clarke, Gwen

Zeller, Michelle ^{[1
,2
,3
]}

Heddle, Nancy M. ^{[1
,2
,7
]}

机构：

[1] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, Hamilton, ON, Canada

[2] McMaster Univ, McMaster Ctr Transfus Res, Dept Med, Hamilton, ON, Canada

[3] Canadian Blood Serv, Hamilton, ON, Canada

[4] McMaster Univ, Dept Pathol, Hamilton Reg Lab Med Program, Hamilton, ON, Canada

[5] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Sherbrooke, PQ, Canada

[6] Univ Calgary, Cumming Sch Med, Community Hlth Sci, Calgary, AB, Canada

[7] Ctr Innovat, Canadian Blood Serv, Ottawa, ON, Canada

[8] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, 280 Main Street West,HSC-3H50, Hamilton, ON L8S 4K1, Canada

来源：

TRANSFUSION | 2023年 / 63卷 / 01期

关键词：

hemolytic disease of fetus and newborn (HDFN); KEL1; Kell; HEMOLYTIC-DISEASE; ANTI-D; BLOOD; PREGNANCIES; ANTIBODIES; PROVISION; NEWBORN; FETUS;

D O I：

10.1111/trf.17201

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundAnti-K is an alloantibody stimulated in response to the KEL1 antigen and may cause hemolytic disease of the fetus and newborn (HDFN). Provision of KEL1 negative blood to females of child-bearing potential was not our practice. We assessed the impact of our policy and assessed feasibility of a KEL1 negative transfusion policy. Study design and methodsThis is a cohort study spanning Jan 1, 2007-Jun 30, 2017 in Hamilton, Canada. Data were obtained via our institution's transfusion database. Chart reviews of females age <= 45 with anti-K were performed; data on RBC KEL1 phenotype were obtained from the blood supplier when needed to ascertain the cause of alloimmunization. Descriptive analysis of hospital KEL1 negative inventory demand and supply was performed. ResultsFrom Jan 2007-Jun 2017, 8.6% of all RBC units transfused were provided to females age <= 45. There were 111 females with detectable anti-K. Median age at time of antibody detection was 34 years (interquartile range 27-40) and 28 of 111 (25.2%) patients may have been alloimmunized by transfusion. Of 49 pregnancies, seven had complications due to anti-K. We estimated that our existing RBC inventory (with 16% units known to be KEL1 negative in 2017) is sufficient to meet demand and support a KEL1 negative transfusion policy for females age <= 45. ConclusionTransfusion was responsible for alloimmunization in 25% of females with anti-K over 10 years. Analysis of supply and demand can be used to inform feasibility of a KEL1 negative transfusion policy.

引用

页码：59 / 68

页数：10