2021 Asia-Pacific Graves' Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves' Disease

被引:12
|
作者
Parameswaran, Rajeev [1 ,2 ]
de Jong, Mechteld Christine [1 ]
Kit, James Lee Wai [1 ]
Sek, Kathleen [3 ]
Tran Quang Nam [4 ]
Tran Viet Thang [4 ]
Nguyen Thy Khue [5 ]
Than Than Aye [6 ]
Phone Myint Tun [7 ]
Cole, Timothy [8 ]
Miller, Julie A. [9 ,10 ]
Villa, Michael [11 ]
Khiewvan, Benjapa [12 ]
Sirinvaravong, Sirinart [13 ]
Sin, Yong Lit [14 ]
Muhammad, Rohaizak [15 ]
Jap, Tjin Shing [16 ]
Agrawal, Amit [17 ]
Rajput, Rajesh [18 ]
Fernando, Ranil [19 ]
Sumanatilleke, Manilka [20 ]
Suastika, Ketut [21 ]
Shong, Young Kee [22 ]
Lang, Brian [23 ]
Bartalena, Luigi [24 ]
Yang, Samantha Peiling [3 ,25 ]
机构
[1] Natl Univ Singapore Hosp, Dept Endocrine Surg, Singapore, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore
[3] Natl Univ Singapore Hosp, Dept Endocrinol, Singapore, Singapore
[4] Univ Med & Pharm, Dept Endocrinol, Ho Chi Minh City, Vietnam
[5] Univ Med & Pharm Ho Chi Minh City, Dept Endocrinol, Ho Chi Minh City, Vietnam
[6] Univ Med 2, Dept Diabet & Endocrinol, Yangon, Myanmar
[7] Grand Hantha Int Hosp, Dept Otolaryngol, Yangon, Myanmar
[8] Monash Univ, Dept Biochem & Mol Biol, Wellington Rd, Clayton, Vic 3800, Australia
[9] Univ Melbourne, Royal Melbourne Hosp, Endocrine Surg Unit, Parkville, Vic, Australia
[10] Univ Melbourne, Dept Surg, Parkville, Vic, Australia
[11] St Lukes Med Ctr, Philippines Ctr Diabet Thyroid & Endocrine Disord, Global City, Taguig, Philippines
[12] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Radiol,Div Nucl Med, Bangkok, Thailand
[13] Mahidol Univ, Siriraj Hosp, Dept Med, Div Endocrinol & Metab, Nakhon, Thailand
[14] Hosp Tuanku Jaafar Seremban, Dept Med, Seremban, Malaysia
[15] Univ Keb Malaysia, Med Ctr, Dept Surg, Kuala Lumpur, Malaysia
[16] Taipei Vet Gen Hosp, Dept Endocrinol, Taipei, Taiwan
[17] Sanjay Gandhi Post Grad Inst Med Sci, Dept Endocrine Surg, Lucknow, Uttar Pradesh, India
[18] Pandit Bhagwat Dayal Sharma Post Grad Inst Med Sc, Dept Endocrinol, Rohtak, Haryana, India
[19] North Colombo Teaching Hosp Ragama, Dept Surg, Ragama, Sri Lanka
[20] Natl Hosp Sri Lanka, Dept Endocrinol, Colombo, Sri Lanka
[21] Udayana Univ, Fac Med, Dept Internal Med, Div Endocrinol & Metab, Bali, Indonesia
[22] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med,Div Endocrinol & Metab, Seoul, South Korea
[23] Queen Mary Hosp, Div Endocrine Surg, Pok Fu Lam, Hong Kong, Peoples R China
[24] Univ Insubria, Div Endocrinol, Varese, Italy
[25] Natl Univ Singapore Hosp, Yong Loo Lin Sch Med, Dept Endocrinol, Singapore, Singapore
关键词
Grave's disease; Thyroidectomy; Anti-thyroid medications; Radioiodine; HYPERTHYROIDISM; DIAGNOSIS; KOREA;
D O I
10.1007/s12020-022-03193-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim Although Graves' disease (GD) is common in endocrine practices worldwide, global differences in diagnosis and management remain. We sought to assess the current practices for GD in countries across Asia and the Pacific (APAC), and to compare these with previously published surveys from North America and Europe. Methods A web-based survey on GD management was conducted on practicing clinicians. Responses from 542 clinicians were received and subsequently analysed and compared to outcomes from similar surveys from other regions. Results A total of 542 respondents participated in the survey, 515 (95%) of whom completed all sections. Of these, 86% were medical specialists, 11% surgeons, and 3% nuclear medicine physicians. In addition to serum thyroid-stimulating hormone (TSH) and free thyroxine assays, most respondents would request TSH-receptor autoantibody (TRAb) measurement (68%) during initial work-up. Thyroid ultrasound is requested by about half of respondents (53%), while the use of nuclear medicine scans is limited. The preferred first-line treatment is anti-thyroid drug (ATD) therapy (79%) with methimazole (MMI) or carbimazole (CBZ), followed by radioiodine (RAI; 19%) and surgery (2%). In case of surgery, one-third of respondents would opt for a subtotal rather than a total thyroidectomy. In case of mild Graves orbitopathy (GO), ATDs (67%) remains the preferred treatment, but a larger proportion of clinicians prefer surgery (20%). For a patient with intention to conceive, the preferred treatment pattern remained unchanged, although propylthiouracil (PTU) became the preferred ATD-agent during the first trimester. In comparison to European and American practices, marked differences were noted in the relatively infrequent usage of nuclear medicine scans and the overall higher use of a ATDs and beta-blockers and adjunctive ATD-treatment during RAI in the APAC-group. Conclusion Although regional differences regarding the diagnosis and management of GD are apparent in this first pan-Asia-Pacific survey, this study reveals the overall approach to the management of this disease in Asia-Pacific generally tends to fall between the trends appreciated in the American and European cohorts.
引用
收藏
页码:135 / 142
页数:8
相关论文
共 50 条
  • [1] 2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease
    Rajeev Parameswaran
    Mechteld Christine de Jong
    James Lee Wai Kit
    Kathleen Sek
    Tran Quang Nam
    Tran Viet Thang
    Nguyen Thy Khue
    Than Than Aye
    Phone Myint Tun
    Timothy Cole
    Julie A. Miller
    Michael Villa
    Benjapa Khiewvan
    Sirinart Sirinvaravong
    Yong Lit Sin
    Rohaizak Muhammad
    Tjin Shing Jap
    Amit Agrawal
    Rajesh Rajput
    Ranil Fernando
    Manilka Sumanatilleke
    Ketut Suastika
    Young Kee Shong
    Brian Lang
    Luigi Bartalena
    Samantha Peiling Yang
    Endocrine, 2023, 79 : 135 - 142
  • [2] A 2011 Survey of Clinical Practice Patterns in the Management of Graves' Disease
    Burch, Henry B.
    Burman, Kenneth D.
    Cooper, David S.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (12): : 4549 - 4558
  • [3] A 2013 European survey of clinical practice patterns in the management of Graves' disease
    Bartalena, L.
    Burch, H. B.
    Burman, K. D.
    Kahaly, G. J.
    CLINICAL ENDOCRINOLOGY, 2016, 84 (01) : 115 - 120
  • [4] A 2017 SURVEY OF THE CLINICAL PRACTICE PATTERNS IN THE MANAGEMENT OF RELAPSING GRAVES DISEASE
    Koren, Shlomit
    Shteinshnaider, Miriam
    Or, Karen
    Cantrell, Dror
    Benbassat, Carlos A.
    Koren, Ronit
    ENDOCRINE PRACTICE, 2019, 25 (01) : 55 - 61
  • [5] A SURVEY OF CLINICAL PRACTICE PATTERNS IN MANAGEMENT OF GRAVES DISEASE IN THE MIDDLE EAST AND NORTH AFRICA
    Beshyah, Salem A.
    Khalil, Aly B.
    Sherif, Ibrahim H.
    Benbarka, Mahmoud M.
    Raza, Syed Abbas
    Hussein, Wiam
    Alzahrani, Ali S.
    Chadli, Asma
    ENDOCRINE PRACTICE, 2017, 23 (03) : 299 - 308
  • [6] A 2023 International Survey of Clinical Practice Patterns in the Management of Graves Disease: A Decade of Change
    Villagelin, Danilo
    Cooper, David S.
    Burch, Henry B.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2024, 109 (11): : 2956 - 2966
  • [8] Practice patterns and outcomes in the management of Thai patients with Graves’ disease
    Yotsapon Thewjitcharoen
    Krittadhee Karndumri
    Waralee Chatchomchuan
    Sriurai Porramatikul
    Sirinate Krittiyawong
    Ekgaluck Wanathayanoroj
    Nampetch Lekpittaya
    Worawit Kittipoom
    Tawee Anuntakulnatee
    Somboon Vongterapak
    Siriwan Butadej
    Soontaree Nakasatien
    Rajata Rajatanavin
    Thep Himathongkam
    Thyroid Research, 14
  • [9] Practice patterns and outcomes in the management of Thai patients with Graves' disease
    Thewjitcharoen, Yotsapon
    Karndumri, Krittadhee
    Chatchomchuan, Waralee
    Porramatikul, Sriurai
    Krittiyawong, Sirinate
    Wanathayanoroj, Ekgaluck
    Lekpittaya, Nampetch
    Kittipoom, Worawit
    Anuntakulnatee, Tawee
    Vongterapak, Somboon
    Butadej, Siriwan
    Nakasatien, Soontaree
    Rajatanavin, Rajata
    Himathongkam, Thep
    THYROID RESEARCH, 2021, 14 (01)
  • [10] A 2015 Italian Survey of Clinical Practice Patterns in the Management of Graves' Disease: Comparison with European and North American Surveys
    Negro, Roberto
    Attanasio, Roberto
    Grimaldi, Franco
    Guglielmi, Rinaldo
    Papini, Enrico
    EUROPEAN THYROID JOURNAL, 2016, 5 (02) : 112 - 119