Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration

被引：29

作者：

Maier, Jeanette A. M. ^{[1
]}

Locatelli, Laura ^{[1
]}

Fedele, Giorgia ^{[1
]}

Cazzaniga, Alessandra ^{[1
]}

Mazur, Andre ^{[2
]}

机构：

[1] Univ Milan, Dept Biomed & Clin Sci, I-20157 Milan, Italy

[2] Univ Clermont Auvergne, UNH Unite Nutr Humaine, INRAE, F-63000 Clermont Ferrand, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 01期

关键词：

magnesium; brain; neuroinflammation; blood-brain barrier; neurodegeneration; NEUROTROPHIC FACTOR BDNF; PARKINSONS-DISEASE; SUBSTANCE-P; SYNAPSE DENSITY; NEURONAL DEATH; DIETARY-INTAKE; MOUSE MODEL; DEFICIENCY; MECHANISM; SULFATE;

D O I：

10.3390/ijms24010223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood-brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer's, and Parkinson's diseases.

引用

页数：14

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