Convalescent Plasma Therapy in Immunocompromised Patients Infected With the BA.1 or BA.2 Omicron SARS-CoV-2

被引：0

作者：

Richier, Quentin ^{[1
]}

De Valence, Benjamin ^{[1
]}

Chopin, Dorothee ^{[1
]}

Gras, Emmanuelle ^{[1
,2
]}

Levi, Laura I. ^{[1
,2
]}

Aad, Yasmine Abi ^{[1
]}

Pacanowski, Jerome ^{[1
]}

Meynard, Jean-Luc ^{[1
]}

Placais, Leo ^{[3
]}

Fey, Dorothee ^{[1
]}

Couture, Priscille ^{[4
]}

Martin-Blondel, Guillaume ^{[5
,6
,7
]}

Pestre, Vincent ^{[8
]}

Woessner, Juliette ^{[8
]}

Ancellin, Sophie ^{[9
]}

Weyrich, Pierre ^{[10
]}

Carpentier, Benjamin ^{[10
]}

Idri, Salim ^{[11
]}

Tiberghien, Pierre ^{[12
,13
]}

Surgers, Laure ^{[1
,2
]}

Hueso, Thomas ^{[14
]}

Lacombe, Karine ^{[1
,2
]}

机构：

[1] Hop St Antoine, AP HP, Serv Malad Infect, Paris, France

[2] Sorbonne Univ, Inserm UMR S1136, IPLESP, Paris, France

[3] Hop Bicetre, Dept Med Interne & Immunol Clin, Le Kremlin Bicetre, France

[4] Hop Foch, Serv Med Interne, Suresnes, France

[5] Ctr Hosp Univ Toulouse, Serv Malad Infect & Trop, F-31300 Toulouse, France

[6] Ctr Physiopathol Toulouse Purpan, INSERM UMR1043, Toulouse, France

[7] Univ Toulouse Paul Sabatier, Fac Med, Toulouse, France

[8] Ctr Hosp Avignon, Serv Med Interne & Malad Infect, Avignon, France

[9] Ctr Hosp Auch, Auch, France

[10] Grp Hop Catholiques Lille, Unite Infectiol, F-59160 Lille, France

[11] Etab Francais Sang, Creteil, France

[12] Etab Francais Sang, La Plaine St Denis, France

[13] UMR 1098 RIGHT Inserm Univ Franche Comte, Etab Francais Sang, Besancon, France

[14] Sorbonne Paris Nord Univ, Hop Avicenne, Serv Radiol, Serv Hematol Clin, Bobigny, France

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2024年 / 18卷 / 03期

关键词：

convalescent plasma; COVID-19; immunocompromised; Omicron variant; SARS-CoV-2;

D O I：

10.1111/irv.13272

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected by the Omicron variant who benefited from COVID-19 convalescent plasma (CCP). At Day 28, the overall survival was 76% (95% CI 67-86) with no significant difference in the clinical outcome between patients with hematological malignancies, solid organ transplantation or autoimmune diseases. No safety concern was reported during the course of the study. These results showed that CCP is well tolerated and represents a treatment option for immunocompromised patients who remain highly impacted by the COVID19 epidemic.

引用

页数：5

共 50 条

[1] Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants
Yu, Jingyou
Collier, Ai-ris Y.
Rowe, Marjorie
Mardas, Fatima
Ventura, John D.
Wan, Huahua
Miller, Jessica
Powers, Olivia
Chung, Benjamin
Siamatu, Mazuba
Hachmann, Nicole P.
Surve, Nehalee
Nampanya, Felix
Chandrashekar, Abishek
Barouch, Dan H.
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (16):
[2] Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions
Xiaoyu Ma
Yanqun Wang
Yuanzhu Gao
Yiliang Wang
An Yan
Jiantao Chen
Lu Zhang
Peiyi Wang
Jincun Zhao
Zheng Liu
Signal Transduction and Targeted Therapy, 8
[3] Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions
Ma, Xiaoyu
Wang, Yanqun
Gao, Yuanzhu
Wang, Yiliang
Yan, An
Chen, Jiantao
Zhang, Lu
Wang, Peiyi
Zhao, Jincun
Liu, Zheng
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
[4] Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England
Elliott, Paul
Eales, Oliver
Steyn, Nicholas
Tang, David
Bodinier, Barbara
Wang, Haowei
Elliott, Joshua
Whitaker, Matthew
Atchison, Christina
Diggle, Peter J.
Page, Andrew J.
Trotter, Alexander J.
Ashby, Deborah
Barclay, Wendy
Taylor, Graham
Ward, Helen
Darzi, Ara
Cooke, Graham S.
Donnelly, Christl A.
Chadeau-Hyam, Marc
SCIENCE, 2022, 376 (6600) : 1432 - +
[5] Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies
Wilhelm, Alexander
Widera, Marek
Grikscheit, Katharina
Toptan, Tuna
Schenk, Barbara
Pallas, Christiane
Metzler, Melinda
Kohmer, Niko
Hoehl, Sebastian
Marschalek, Rolf
Herrmann, Eva
Helfritz, Fabian A.
Wolf, Timo
Goetsch, Udo
Ciesek, Sandra
EBIOMEDICINE, 2022, 82
[6] Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Mykytyn, Anna Z.
Rissmann, Melanie
Kok, Adinda
Rosu, Miruna E.
Schipper, Debby
Breugem, Tim, I
van den Doel, Petra B.
Chandler, Felicity
Bestebroer, Theo
de Wit, Maurice
van Royen, Martin E.
Molenkamp, Richard
Munnink, Bas B. Oude
de Vries, Rory D.
GeurtsvanKessel, Corine
Smith, Derek J.
Koopmans, Marion P. G.
Rockx, Barry
Lamers, Mart M.
Fouchier, Ron A. M.
Haagmans, Bart L.
SCIENCE IMMUNOLOGY, 2022, 7 (75)
[7] Antibody Titers and Protection against Omicron (BA.1 and BA.2) SARS-CoV-2 Infection
Dimeglio, Chloe
Migueres, Marion
Bouzid, Naemie
Chapuy-Regaud, Sabine
Gernigon, Caroline
Da-Silva, Isabelle
Porcheron, Marion
Martin-Blondel, Guillaume
Herin, Fabrice
Izopet, Jacques
VACCINES, 2022, 10 (09)
[8] SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated rhesus macaques as compared to Delta
van Doremalen, Neeltje
Singh, Manmeet
Saturday, Taylor A.
Yinda, Claude Kwe
Perez-Perez, Lizzette
Bohler, W. Forrest
Weishampel, Zachary A.
Lewis, Matthew
Schulz, Jonathan E.
Williamson, Brandi N.
Meade-White, Kimberly
Gallogly, Shane
Okumura, Atsushi
Feldmann, Friederike
Lovaglio, Jamie
Hanley, Patrick W.
Shaia, Carl
Feldmann, Heinz
de Wit, Emmie
Munster, Vincent J.
Rosenke, Kyle
SCIENCE ADVANCES, 2022, 8 (46)
[9] Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus
Richter, Jan
Koptides, Dana
Tryfonos, Christina
Alexandrou, Denise
Christodoulou, Christina
MICROORGANISMS, 2022, 10 (09)
[10] Comparison of SARS-CoV-2 Viral Loads in the Nasal Mucosa of Patients Infected With BA.1, BA.2, or BA.5 Omicron Lineages
Tozer, Kyla
Sjaarda, Calvin P.
Moslinger, Emily
Wong, Henry
Mubareka, Samira
Maguire, Finlay
Fattouh, Ramzi
Brabant-Kirwan, Danielle
Kozak, Robert
Sheth, Prameet M.
OPEN FORUM INFECTIOUS DISEASES, 2022, 9 (12):

← 1 2 3 4 5 →