To comprehend the empirical seismic vulnerability capability of various typical structures in towns and suburbs, this study considers, as the research background, the structural damage data observation from the Mw 7.1 Yushu earthquake that occurred on 2010 April 14th in China. The proposed research activity sorts out the actual investigation data (7156 buildings) of five types of typical structures in towns and villages and establishes the vulnerability and seismic fragility evaluation model of a group of buildings considering multidimensional parameters by using the Chinese macroseismic intensity standard. Using spatial modal, numerical calculation, and regression analysis methods, an updated lognormal distribution vulnerability and resilience assessment model based on multidimensional quantitative parameters is performed. Based on the principle of the conditional probability and damage quantification model, an innovative model (domain, point cloud, curve, surface, matrix, and function) is established for regional vulnerability and seismic resilience assessment of typical group buildings. A logarithmic relationship model considering both the updated Chinese macroseismic intensity and three-dimensional composite peak ground acceleration as intensity measures is proposed, and an empirical vulnerability assessment model for typical rural buildings is established. The traditional average earthquake loss index calculation model is updated, and an innovative regional domain vulnerability assessment model is conducted. Taking the samples of various typical structures surveyed in the Yushu earthquake, regional group structure vulnerability domain comparison models of various structures are performed. Ultimately, depending on the typical damage characteristics of structures, the actual damage features and mechanisms of various structures are analysed.