Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies

被引：2
|
作者：
Van Roessel, Ichelle Maa [1 ,2 ]
Bakker, Boudewijn [1 ,2 ]
Van Santen, Hanneke M. [1 ,2 ]
Chemaitilly, Wassim [3 ]
机构：
[1] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Pediat Endocrinol, Utrecht, Netherlands
[2] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands
[3] UPMC Childrens Hosp Pittsburgh, Div Pediat Endocrinol, Pittsburgh, PA 15224 USA
来源：
ENDOCRINE CONNECTIONS | 2023年 / 12卷 / 01期
关键词：
childhood cancer; childhood brain tumors; growth hormone; hypothyroidism; hypogonadism; PREMATURE OVARIAN INSUFFICIENCY; CENTRAL-NERVOUS-SYSTEM; LONG-TERM MORTALITY; GERM-CELL TUMOR; GROWTH-HORMONE; BREAST-CANCER; THYROID-FUNCTION; PEDIATRIC-PATIENTS; RAPID ENLARGEMENT; 2ND NEOPLASMS;
D O I：
10.1530/EC-22-0382
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This article offers a summary of current knowledge, controversies and areas for future research pertaining to this area.
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页数：7
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