Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis

被引：2
|
作者：
Qiu, Xiangmei [1 ]
Zhang, Qiang [1 ]
Deng, Qingfang [1 ]
Li, Quan [1 ]
机构：
[1] Zunyi Med Univ, Dept Obstet & Gynecol, Affiliated Hosp, 149 Dalian Rd, Zunyi 563000, Guizhou, Peoples R China
来源：
MOLECULAR BIOTECHNOLOGY | 2023年 / 65卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; hsa_circ_0012673; Proliferation; Invasion; PROLIFERATION; CELLS; CONTRIBUTES; RESISTANCE; EXPRESSION; INVASION; SPONGE;
D O I：
10.1007/s12033-022-00524-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circular RNAs (circRNAs) have been reported to exert critical roles in human cancers. In this study, we investigated the role and molecular mechanism of hsa_circ_0012673 in breast cancer. Herein, we found that the expression of hsa_circ_0012673 was upregulated in breast cancer tissues and cell lines. Knockdown of hsa_circ_0012673 using RNA interference technique suppressed the proliferation, migration, and invasion of breast cancer cells. Mechanistically, hsa_circ_0012673 sponged miR-576-3p to stabilize SRY-box transcription factor 4 (SOX4), and thereby facilitating breast cancer cell proliferation, migration and invasion. Collectively, our study identified the oncogenic properties of hsa_circ_0012673/miR-576-3p/SOX4 axis in breast cancer, providing potential and exploitable diagnostic and therapeutic molecules for breast cancer.
引用
收藏
页码：61 / 71
页数：11
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