Synthesis and In-vivo Bioactivity Studies of Some New Hydrazide Schiff Bases and Mannich Bases of Indole Derivatives

被引：0

作者：

Subramanyam, S. ^{[1
]}

Samineni, Ramu ^{[1
]}

Kadiri, Sunil Kumar ^{[2
]}

Yanadaiah, J. P. ^{[3
]}

Jonnalagedda, Phaneendranath ^{[4
]}

Chikkula, Krishna Veni ^{[5
]}

Gouru, Sampath A. ^{[6
]}

机构：

[1] Vignans Fdn Sci Technol & Res, Dept Pharmaceut Sci, Sch Biotechnol & Pharmaceut Sci, Guntur, Andhra Pradesh, India

[2] Davananda Sagar Univ, Coll Pharmaceut Sci, Dept Pharm, K S Layout, Bengaluru, Karnataka, India

[3] Erstwhile Sree Vidyanikethan Coll Pharm, Dept Pharm, Mohan Babu Sch Pharmaceut Sci, Tirupati, Andhra Pradesh, India

[4] Agati Clin Informat LLP, Lead Stat Programmer, Bengaluru, Karnataka, India

[5] Sarojini Naidu Vanita Pharm Maha Vidyalaya, Dept Pharmaceut Chem, Secunderabad, Telangana, India

[6] EQRX Int Inc, Dept Qual Assurance, Cambridge, MA 02139 USA

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 33卷 / 03期

关键词：

Indole derivatives; Hydrazide Schiff bases; Mannich bases; Anti-inflammatory; Analgesic; Antiulcer; ANTI-HIV;

D O I：

10.59467/IJHC.2023.33.299

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The anti-inflammatory, analgesic, and antiulcer activities of eight new hydrazide Schiff bases and eight new Mannich bases of indole derivatives were investigated. 2-Methyl-1H-indole-3-carboxylate (III) on hydrazinolysis gave 2-methyl-1H-indole-3-carbohydrazide (IV), which on reaction with aldehydes gave corresponding hydrazide Schiff bases Va-Vh. The reaction of IV with formaldehyde, different aliphatic, aromatic, and heterocyclic amines afforded the Mannich bases of indole derivatives (VIa-VIe). The results of biological studies revealed that Schiff bases with 2,4-dichlorobenzaldehyde (Vh) and 2-chlorobenzaldehyde (Vb) were potent anti-inflammatory, analgesic, and antiulcer activities. Mannich bases (VIh and VIc) having -NO2 and -Cl groups in the paralocation of the heterocyclic nucleus displayed effective anti-inflammatory, analgesic, and antiulcer activities.

引用

页码：299 / 309

页数：11

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