Visible-light-driven intramolecular xanthylation of remote unactivated C(sp3)-H bonds

被引：19

作者：

Chen, Hang ^{[2
]}

Zhou, Yang ^{[2
]}

Lei, Panpan ^{[2
]}

Wang, Haifeng ^{[1
]}

Yan, Qiongjiao ^{[1
]}

Properzi, Roberta ^{[5
]}

Wang, Wei ^{[1
]}

Jing, Linhai ^{[1
,2
]}

Chen, Fener ^{[1
,3
,4
]}

机构：

[1] Wuhan Inst Technol, Pharmaceut Res Inst, Wuhan 430205, Peoples R China

[2] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637009, Peoples R China

[3] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China

[4] Shanghai Engn Ctr Ind Catalysis Chiral Drugs, Shanghai 200433, Peoples R China

[5] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

GREEN SYNTHESIS AND CATALYSIS | 2023年 / 4卷 / 04期

基金：

中国国家自然科学基金;

关键词：

C -H functionalization; 5 -Hydrogen atom transfer; Photocatalytic; Site -speci fic; Xanthylation; RADICAL REACTIONS; FUNCTIONALIZATIONS; CHEMISTRY; SKELETON; ROUTE;

D O I：

10.1016/j.gresc.2022.07.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visible light-mediated site-specific C(sp3)-H xanthylation of amides has been accomplished using N-xanthylamides. The N-centered radicals generated by light initiation of N-xanthylamide substrates undergo 1,5-hydrogen atom transfer to form benzylic or alkyl radical intermediates under metal-and catalyst-free conditions. This method exhibits a broad substrate scope, high functional group tolerance, and high regioselectivity. Furthermore, this strategy provides straightforward access to a range of derivatives through the subsequent elaboration of the xanthate group.

引用

页码：350 / 354

页数：5

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