Coscinoderines A-J: Trisubstituted Pyridinium-Containing Norterpenoids Isolated from Coscinoderma bakusi, a Tropical Marine Sponge

被引：6

作者：

Tran, Huynh Nguyen Khanh ^{[1
]}

Kim, Min Jin ^{[1
]}

Shin, A-Young ^{[1
]}

Tran, Le Viet Ha ^{[1
]}

Lee, Jihoon ^{[1
,2
]}

Lee, Yeon-Ju ^{[1
,2
]}

机构：

[1] Korea Inst Ocean Sci & Technol, Marine Nat Prod Chem Lab, 385 Haeyang Ro, Busan 49111, South Korea

[2] Univ Sci & Technol, Dept Marine Biotechnol, Daejeon 34113, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2023年 / 86卷 / 09期

关键词：

SESTERTERPENOIDS; ALKALOIDS; PORIFERA; SALTS;

D O I：

10.1021/acs.jnatprod.3c00358

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new norterpene alkaloids, coscinoderines A-J (1-10), were isolated from the marine sponge Coscinoderma bakusi. Each coscinoderine contains a 1,2,5-trisubstituted pyridinium moiety bearing a terpene unit at the C-2 position. Their structures were elucidated by analysis of NMR and HRMS data, and the absolute stereochemistry of 4 with a 2-methylbutyl group attached to the nitrogen was determined from a comparison of the calculated and measured ECD spectra. The isolation of coscinoderines expands the repertoire of pyridinium alkaloids isolated from marine sponges.

引用

页码：2145 / 2150

页数：6