Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023

被引：9
|
作者：
Andreev, Konstantin [1 ]
Jones, Jeremy C. [1 ]
Seiler, Patrick [1 ]
Kandeil, Ahmed [1 ]
Turner, Jasmine C. M. [1 ]
Barman, Subrata [1 ]
Rubrum, Adam M. [1 ]
Webby, Richard J. [1 ]
Govorkova, Elena A. [1 ,2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Host Microbe Interact, Memphis, TN USA
[2] St Jude Childrens Res Hosp, Dept Host Microbe Interact, 262 Danny Thomas Pl, Memphis, TN 38105 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2023年 / 229卷 / 06期
基金：
美国国家卫生研究院;
关键词：
resistance; avian influenza; baloxavir; neuraminidase inhibitors; NEURAMINIDASE INHIBITORS; REDUCED SENSITIVITY; H5N1;
D O I：
10.1093/infdis/jiad418
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The antiviral susceptibility of currently circulating (2022-2023) highly pathogenic avian influenza (HPAI) A(H5N1) viruses was assessed by genotypic and phenotypic approaches. The frequency was low for neuraminidase (NA) and polymerase acidic (PA) substitutions associated with reduced inhibition by NA inhibitors (21/2698, 0.78%) or the PA inhibitor baloxavir (14/2600, 0.54%). Phenotypic testing of 22 clade 2.3.2.1a and 2.3.4.4b viruses revealed broad susceptibility to NA inhibitors and baloxavir for a conclusion that most contemporary HPAI A(H5N1) viruses retain susceptibility to antiviral drugs. Novel NA-K432E and NA-T438I substitutions (N2 numbering) were identified at elevated frequencies (104/2698, 3.85%) and caused reduced zanamivir and peramivir inhibition.
引用
收藏
页码：1830 / 1835
页数：6
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