Supplementation with alpha-glycerol monolaurate during late gestation and lactation enhances sow performance, ameliorates milk composition, and improves growth of suckling piglets

BackgroundPhysiological changes during lactation cause oxidative stress in sows, reduce immunity, and hamper the growth capacity of piglets. Alpha-glycerol monolaurate (alpha-GML) has potential for enhancing the antimicrobial activity of sows and the growth of suckling piglets.MethodsEighty sows were allocated randomly to four groups: basal diet and basal diets supplemented with 500, 1000, or 2000 mg/kg alpha-GML. The experiment started on d 85 of gestation and lasted until piglets were weaned on d 21 of lactation. The number of live-born piglets was standardized to 12 +/- 1 per sow on day of parturition. On d 0 and 21 of lactation, body weight of piglets was measured and milk samples were obtained from sows, and serum samples and feces from piglets were obtained on d 21.ResultsFeed intake, backfat loss, and weaning estrus interval did not differ among the four groups of sows. Maternal alpha-GML supplementation increased (P < 0.05) the body weight of piglets at weaning and the apparent total tract digestibility of crude fat of sows. The immunoglobulin A and immunoglobulin G levels were greater (P < 0.05) in a quadratic manner in the milk of sows as dietary alpha-GML increased. Concerning fatty acid profile, C12:0, C15:0, C17:0, C18:2n6c, C18:3n3, C24:0, and C22:6n3 were higher (P < 0.05) in linear and quadratic manners in colostrum of sows-fed alpha-GML diets compared with the control sows. There was lower (P < 0.05) n-6:n-3 polyunsaturated fatty acid ratio in milk than in the control sows. Maternal alpha-GML increased the abundance of Firmicutes (P < 0.05) and decreased the abundance of Proteobacteria (P < 0.05) of piglet fecal microbiota.ConclusionsDietary supplementation with alpha-GML improved milk immunoglobulins and altered fatty acids of sows, thereby improving the health of piglets.