Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study

被引：4

作者：

Ibrahim, Bakari ^{[1
,8
]}

Achour, Djamal ^{[2
]}

Zerimech, Farid ^{[2
]}

de Nadai, Patricia ^{[3
]}

Siroux, Valerie ^{[4
]}

Tsicopoulos, Anne ^{[3
]}

Matran, Regis ^{[5
]}

Granger, Vanessa ^{[6
,7
]}

Nadif, Rachel ^{[1
]}

机构：

[1] Univ Paris Saclay, Univ Paris Sud, Equipe Epidemiol Resp Integrat, UVSQ,INSERM,CESP, Paris, France

[2] Univ Lille, Inst Pasteur Lille, CHU Lille, EA 4483,IMPECS, Lille, France

[3] Univ Lille, Inst Pasteur Lille, CIIL Ctr Infect & Immun Lille, CNRS,INSERM,CHU Lille,U1019,UMR9017, F-59000 Lille, France

[4] Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inserm, CNRS,IAB, Grenoble, France

[5] Univ Lille, Inst Pasteur Lille, CHU Lille, ULR 4483, Lille, France

[6] Univ Paris Saclay, Inserm, Inflammat Microbiome immunosurveillance, Paris, France

[7] Hop Bichat Claude Bernard, APHP, UF Autoimmun Hypersensibil & Biotherapies, HUPNVS, Paris, France

[8] CESP, Epidemiol Respiratoire Integrat, F-94800 Villejuif, France

来源：

THORAX | 2023年 / 78卷 / 02期

关键词：

Asthma; Asthma Epidemiology; Cytokine Biology;

D O I：

10.1136/thorax-2022-219192

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma.Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later.Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.

引用

页码：207 / 210

页数：4

共 50 条

[1] Thymic stromal lymphopoietin (TSLP) in naturally occurring asthma exacerbations in adults
Bjerregard, Asger
Baltic, Svetlana
Barrett, Lucy
Thompson, Phillip
Backer, Vibeke
Fally, Markus
Laing, Ingrid
Khoo, Siew-Kim
Le Souef, Peter
Porsbjerg, Celeste
EUROPEAN RESPIRATORY JOURNAL, 2016, 48
[2] Tezepelumab Anti-TSLP (thymic stromal lymphopoietin) Treatment of severe asthma
Yao, Y.
Ali, Z.
Thomsen, S. F.
DRUGS OF THE FUTURE, 2021, 46 (07) : 529 - 536
[3] Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma
Bunyavanich S.
Melen E.
Wilk J.B.
Granada M.
Soto-Quiros M.E.
Avila L.
Lasky-Su J.
Hunninghake G.M.
Wickman M.
Pershagen G.
O'Connor G.T.
Weiss S.T.
Celedn J.C.
Clinical and Molecular Allergy, 9 (1)
[4] Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma
Sebastian K.
Borowski A.
Kuepper M.
Friedrich K.
Cell Communication and Signaling, 6 (1)
[5] Thymic stromal lymphopoietin (TSLP) and the atopic march
Chambon, P.
REVUE FRANCAISE D ALLERGOLOGIE, 2010, 50 (03): : 94 - 97
[6] A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype
Iijima, Hiroaki
Kaneko, Yoshiko
Yamada, Hideyasu
Yatagai, Yohei
Masuko, Hironori
Sakamoto, Tohru
Naito, Takashi
Hirota, Tomomitsu
Tamari, Mayumi
Konno, Satoshi
Nishimura, Masaharu
Noguchi, Emiko
Hizawa, Nobuyuki
ALLERGOLOGY INTERNATIONAL, 2013, 62 (01) : 123 - 130
[7] Analysing disease-specific variants of thymic stromal lymphopoietin (TSLP) in asthma
Donaldson, Jessica
Smart, David
Swindle, Emily
Edwards, Matt
Howarth, Peter
Davies, Donna E.
EUROPEAN RESPIRATORY JOURNAL, 2015, 46
[8] Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma
Smolinska, Sylwia
Antolin-Amerigo, Dario
Popescu, Florin-Dan
Jutel, Marek
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (16)
[9] Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma
Han, H.
Xu, W.
Headley, M. B.
Jessup, H. K.
Lee, K. S.
Omori, M.
Comeau, M. R.
Marshak-Rothstein, A.
Ziegler, S. F.
MUCOSAL IMMUNOLOGY, 2012, 5 (03) : 342 - 351
[10] S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
Pierre-Alexandre Gagnon
Martin Klein
John De Vos
Sabrina Biardel
Andréanne Côté
Krystelle Godbout
Michel Laviolette
Catherine Laprise
Said Assou
Jamila Chakir
Respiratory Research, 24

← 1 2 3 4 5 →