Child abuse and neglect is a 'wicked problem' ( 'Child abuse as a complex and wicked problem: Reflecting on policy developments in the United Kingdom in working with children and families with multiple problems', Children and Youth Services Review, 31(6), pp. 635-41.). Child Protection and Welfare (CPW) systems are open systems in which a wide variety of practitioners and families themselves contribute to outcomes. Small interacting changes in one part of a CPW system can lead to unpredictable and systemic effects so linear, technocratic solutions are not sufficient in addressing this complexity. Whilst CPW systems may aim to make clear roles and responsibilities, steered by legislation and regulatory guidance, complex systems do not behave as system designers expect. Recent literature has demonstrated a turn to complexity theory and systems theory concepts for understanding and working in the world of child protection. This article suggests a practice framework based on complexity theory concepts of self-organisation/emergence/adaptation, path-dependency and bifurcation. The utility of the framework is tested by its application to a fictionalised case study built on a thematic analysis of five National Review Panel published case reviews in the Irish child protection context (2019-2020). We argue that complexity theory may be a useful tool for both post hoc analytics as well as providing a proactive tool for application to practice to assist decision making in CPW systems, services and organisations. Child abuse and neglect is a 'wicked problem' (). Complexity Theory has historically been critiqued for lacking explanatory power and transferability to social contexts. This article suggests a practice framework based on complexity theory concepts of self-organisation/emergence/adaptation, path-dependency and bifurcation to assist practitioners and managers to adopt a holistic socio-technical approach to child protection practice. The utility of the framework is tested by its application to a fictionalised case study built on a thematic analysis of five National Review Panel published case reviews in the Irish child protection context (2019-2020). Our findings suggest that even though adopting a complexity lens to CPW work can be challenging, it can assist practitioners and managers to consider risk, volatility and relationships in child protection work in a more open way in practice and through case review. At the case level, a complexity focus allows practitioners to reflect in the first place on the system that they are part of and to consider who are the key practitioners, teams and networks that they need to interact with and how. At the system level, a complexity focus reinforces the importance of interactional, transactional and collaborative approaches to child protection and welfare work.