The Therapeutic Effects of Noninvasive Brain Stimulation Combined with Cognitive Training in Elders with Alzheimer's Disease or Amnesic Mild Cognitive Impairment

被引:1
|
作者
Wang, J. -Y [1 ,2 ]
Qin, J. -Y [3 ]
Ye, J. -Y [2 ]
Li, W. -T [4 ]
Tong, M. -Q-Z [2 ]
Ouyang, Hui [2 ,5 ]
Yan, Fengxia [3 ,6 ]
机构
[1] Shantou Univ, Longgang Dist Matern & Child Healthcare Hosp Shenz, Dept Rehabil, Med Coll,Longgang Matern & Child Inst, Shenzhen, Guangdong, Peoples R China
[2] Jinan Univ, Dept Rehabil, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
[3] Jinan Univ, Sch Nursing, Guangzhou, Guangdong, Peoples R China
[4] Jiangmen Cent Hosp, Dept Rehabil, Jiangmen, Guangdong, Peoples R China
[5] Jinan Univ, Dept Rehabil, Affiliated Hosp 1, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China
[6] Jinan Univ, Sch Nursing, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China
来源
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; amnesic mild cognitive impairment; noninvasive brain stimulation; cognitive interval; DOUBLE-BLIND; INTERVENTION;
D O I
10.14283/jpad.2024.1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BackgroundRecent studies have indicated that noninvasive brain stimulation combined with cognitive interval (NIBS-CI) improved cognitive function in people with Alzheimer's disease (AD) or Amnesic mild cognitive impairment (a-MCI). While previous interventions have demonstrated that a single targeted cognitive intervention can improve cognitive function, the outcomes of using both interventions simultaneously are less well-established. Therefore, this study aims to perform a meta-analysis to determine the effectiveness of NIBS-CI in treating cognitive impairment associated with AD and a-MCI, with the goal of obtaining novel insights into this combined intervention.MethodsPubMed, Web of Science, ProQuest and Central Cochrane library databases were searched up to December 2022. The primary cognitive outcomes were extracted from the included article. A mean difference (MD) and standardized mean difference (SMD) with a 95% confidence interval were calculated by using random-effect models.ResultsTwelve studies with a total of 587 AD patients were included. The findings demonstrated that NIBS-CI significantly improved cognitive function of AD patients in cognitive outcomes (SMD = -0.52, 95%CI (-0. 93, -0.11)) and ADAS-COG (MD = -1.16, 95%CI (-1.69, -0.63)). The pooled results showed that NIBS-CI did not improve cognitive function of AD patients in short-time memory (SMD = 0.057, 95%CI (-0.13, 0.25), P = 0.56) and long-time memory (SMD = 0.001, 95%CI (-0.20, 0.20), P = 0.99).ConclusionsThere is evidence for a positive effect of NIBS-CI on overall cognitive function of AD and a-MCI. Considering the limited sample size, it is important to interpret the findings related to memory with caution. To obtain more robust results, future studies should be conducted with larger sample sizes and incorporate objective neurophysiological and neuroimaging tools. These methodological enhancements will allow for a better understanding of the therapeutic targets and provide a more comprehensive assessment of the effects of NIBS-CI treatment.
引用
收藏
页码:382 / 401
页数:20
相关论文
共 50 条
  • [1] The Therapeutic Effects of Noninvasive Brain Stimulation Combined with Cognitive Training in Elders with Alzheimer’s Disease or Amnesic Mild Cognitive Impairment
    J.-Y. Wang
    J.-Y. Qin
    J.-Y. Ye
    W.-T. Li
    M.-Q.-Z. Tong
    Hui Ouyang
    Fengxia Yan
    The Journal of Prevention of Alzheimer's Disease, 2024, 11 : 222 - 229
  • [2] Effects of Noninvasive Brain Stimulation (NIBS) on Cognitive Impairment in Mild Cognitive Impairment and Alzheimer Disease A Meta-analysis
    Wang, Tao
    Guo, Zhiwei
    Du, Yonghui
    Xiong, Ming
    Yang, Zhengcong
    Ren, Long
    He, Lin
    Jiang, Yi
    McClure, Morgan A.
    Mu, Qiwen
    ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2021, 35 (03): : 278 - 288
  • [3] The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis
    Yang, Ting
    Liu, Wentao
    He, Jiali
    Gui, Chenfan
    Meng, Lijiao
    Xu, Li
    Jia, Chengsen
    ALZHEIMERS RESEARCH & THERAPY, 2024, 16 (01)
  • [4] Cognitive stimulation in mild cognitive impairment and early stage Alzheimer's disease
    Rigaud, AS
    de Rotrou, J
    Cantegreil, I
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S124 - S124
  • [5] Structural and functional brain connectome architecture in Alzheimer's disease and amnesic mild cognitive impairment patients
    Filippi, Massimo
    Basaia, Silvia
    Canu, Elisa
    Galantucci, Sebastiano
    Meani, Alessandro
    Caso, Francesca
    Magnani, Giuseppe
    Santangelo, Roberto
    Falautano, Monica
    Falini, Andrea
    Comi, Giancarlo
    Agosta, Federica
    NEUROLOGY, 2017, 88
  • [6] Structural and functional brain connectome architecture in Alzheimer's disease and amnesic mild cognitive impairment patients
    Agosta, F.
    Basaia, S.
    Canu, E.
    Galantucci, S.
    Meani, A.
    Caso, F.
    Magnani, G.
    Santangelo, R.
    Falautano, M.
    Falini, A.
    Comi, G.
    Filippi, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2017, 24 : 445 - 445
  • [7] Brain imaging of mild cognitive impairment and Alzheimer's disease
    Yin, Changhao
    Li, Siou
    Zhao, Weina
    Feng, Jiachun
    NEURAL REGENERATION RESEARCH, 2013, 8 (05) : 435 - 444
  • [8] Brain imaging of mild cognitive impairment and Alzheimer's disease
    Changhao Yin
    Siou Li
    Weina Zhao
    Jiachun Feng
    Neural Regeneration Research, 2013, 8 (05) : 435 - 444
  • [9] Spect-neuropsychology correlations in very mild Alzheimer's disease and amnesic mild cognitive impairment
    Ricci, Monica
    Todino, Valerio
    Magarelli, Maria
    Montecucco, Ilaria
    Ruggeri, Massimiliano
    Gerace, Carmela
    Blundo, Carlo
    ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2020, 89
  • [10] A Pilot Study on Brain Plasticity of Functional Connectivity Modulated by Cognitive Training in Mild Alzheimer's Disease and Mild Cognitive Impairment
    Barban, Francesco
    Mancini, Matteo
    Cercignani, Mara
    Adriano, Fulvia
    Perri, Roberta
    Annicchiarico, Roberta
    Carlesimo, Giovanni Augusto
    Ricci, Claudia
    Lombardi, Maria Giovanna
    Teodonno, Valeria
    Serra, Laura
    Giulietti, Giovanni
    Fadda, Lucia
    Federici, Alessia
    Caltagirone, Carlo
    Bozzali, Marco
    BRAIN SCIENCES, 2017, 7 (05)