Phytochemical study of Magonia pubescens A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells

被引：3

作者：

Moraes, Acacio R. A. ^{[1
]}

Siqueira, Ezequias P. ^{[2
]}

Kohlhoff, Markus ^{[2
]}

Evangelista, Fernanda C. G. ^{[3
]}

Sabino, Adriano P. ^{[3
]}

Vieira Filho, Sidney A. ^{[4
]}

Alcantara, Antonio F. C. ^{[1
]}

Duarte, Lucienir P. ^{[1
]}

Sousa, Grasiely F. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, Inst Ciencia Exatas, Belo Horizonte, MG, Brazil

[2] Inst Rene Rachou Fiocruz Minas, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Farm, Dept Anal Clin & Toxicol, Belo Horizonte, MG, Brazil

[4] Univ Fed Ouro Preto, Dept Quim, Ouro Preto, MG, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 11期

关键词：

Magonia pubescensA; St; -Hil; cytotoxicity; breast cancer cells; leukemia cells; UHPLC-MS; MS;

D O I：

10.1080/14786419.2023.2227988

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Magonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared with data from three databases, leading to the putative identification of 51 compounds from different classes, including flavonoids, saponins and triterpenes. The cytotoxicity of aqueous fractions was assayed against breast cancer (MDA-MB-231) and leukemia (THP-1 and K562) cells. The best activity was observed for fraction AE3 against MDA-MB-231 cells (IC50 30.72 & mu;g.mL(-1)).

引用

页码：1956 / 1960

页数：5

共 11 条

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