Estimation of Analyte's Vertical Positions above the Surface of Nanocapacitor Array Biosensors

被引：1
|
作者：
Goldoni, Daniele [1 ]
Ongaro, Claudio [1 ]
Orazi, Leonardo [2 ,3 ]
Rovati, Luigi [1 ]
Selmi, Luca [1 ]
机构：
[1] Univ Modena & Reggio Emilia, Dept Engn Enzo Ferrari DIEF, Modena, Italy
[2] Univ Modena & Reggio Emilia, Dept Sci & Methods Engn DISMI, Modena, Italy
[3] Univ Modena & Reggio Emilia, Interdept Ctr EN&TECH, Reggio Emilia, Italy
来源：
2023 IEEE SENSORS | 2023年
关键词：
biosensor arrays; nano-capacitor array; high frequency impedance spectroscopy; nanoparticle position estimation; numerical simulations; CHANNEL;
D O I：
10.1109/SENSORS56945.2023.10325169
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel method is proposed to estimate the vertical position of analytes above the surface of nanoelectrode array biosensors, which monitor the capacitance fluctuations caused by analytes in a microfluidic channel. The position estimation method, which takes advantage of accurate physics-based numerical simulations and simple analytical models, is tested on measurements of polystyrene nanoparticles (NPs) with an advanced high frequency impedance spectroscopy platform equipped with a new and optimized microfluidic chamber. The NP height estimation is directly validated on physics-based numerical simulations. In addition, it is indirectly confirmed by showing that numerical simulations with random NP positions (in agreement with the experimental height distribution) yield response distributions closely matching their measured counterpart.
引用
收藏
页数：4
相关论文
共 15 条
  • [1] Bayesian estimation of physical and geometrical parameters for nanocapacitor array biosensors
    Stadlbauer, Benjamin
    Cossettini, Andrea
    Morales, Jose A. E.
    Pasterk, Daniel
    Scarbolo, Paolo
    Taghizadeh, Leila
    Heitzinger, Clemens
    Selmi, Luca
    JOURNAL OF COMPUTATIONAL PHYSICS, 2019, 397
  • [2] Integration of a surface-directed microfluidic system with an organic electrochemical transistor array for multi-analyte biosensors
    Yang, Sang Y.
    DeFranco, John A.
    Sylvester, Yuri A.
    Gobert, Thomas J.
    Macaya, Daniel J.
    Owens, Roisin M.
    Malliaras, George G.
    LAB ON A CHIP, 2009, 9 (05) : 704 - 708
  • [3] The vertical distribution of air temperature in the first two metres above the earth's surface
    Seitzer, P
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES, 1933, 196 : 1626 - 1628
  • [4] Spectral Analysis of a Nanodipole Array above the Surface Impedance of Graphene by Green's Function
    Cruz, A. F. S.
    Del Rosso, T.
    Dmitriev, V.
    Costa, K. Q.
    2019 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), 2019,
  • [5] METHOD OF ESTIMATION OF VERTICAL MOVEMENTS OF THE EARTH 'S SURFACE IN UNDER-WORKED AREAS
    Sarychev, V., I
    Safronov, V. P.
    Zaytsev, Y., V
    Romanyuk, A., V
    PROCEEDINGS OF THE TULA STATES UNIVERSITY-SCIENCES OF EARTH, 2020, 4 : 250 - 262
  • [6] 4 x 15 Gbit/s 850 nm Vertical Cavity Surface Emitting Laser Array
    Lu Zhaochen
    Wang Qing
    Yao Shun
    Zhou Guangzheng
    Yu Hongyan
    Li Ying
    Lang Luguang
    Lan Tian
    Zhang Wenjia
    Liang Chenyu
    Zhang Yang
    Zhao Fengchun
    Jia Haifeng
    Wang Guanghui
    Wang Zhiyong
    ACTA OPTICA SINICA, 2018, 38 (05)
  • [7] The vertical turbulent structure within the surface boundary layer above a Vineyard in California’s Central Valley during GRAPEX
    Joseph G. Alfieri
    William P. Kustas
    John H. Prueger
    Lynn G. McKee
    Lawrence E. Hipps
    Nicolas Bambach
    Irrigation Science, 2022, 40 : 481 - 496
  • [8] The vertical turbulent structure within the surface boundary layer above a Vineyard in California's Central Valley during GRAPEX
    Alfieri, Joseph G.
    Kustas, William P.
    Prueger, John H.
    McKee, Lynn G.
    Hipps, Lawrence E.
    Bambach, Nicolas
    IRRIGATION SCIENCE, 2022, 40 (4-5) : 481 - 496
  • [9] MULTIGIGABIT/S OPERATION OF 16-WAVELENGTH VERTICAL-CAVITY SURFACE-EMITTING LASER ARRAY
    MAEDA, MW
    CHANGHASNAIN, C
    VONLEHMEN, A
    IZADPANAH, H
    LIN, C
    IQBAL, MZ
    FLOREZ, L
    HARBISON, J
    IEEE PHOTONICS TECHNOLOGY LETTERS, 1991, 3 (10) : 863 - 865
  • [10] Analyte-receptor binding on surface plasmon resonance biosensors:: a fractal analysis of Cre-loxP interactions and the influence of Cl, O, and S on drug-liposome interactions
    Butala, HD
    Tan, YQ
    Sadana, A
    ANALYTICAL BIOCHEMISTRY, 2004, 332 (01) : 10 - 22
12