Review on nitric oxide at the forefront of rapid systemic signaling in mitigation of salinity stress in plants: Crosstalk with calcium and hydrogen peroxide

Soil salinity is a global issue that limits plant growth in agricultural fields and contributes to food crisis. Salt stressors impede plant's ionic, osmotic, and oxidative balance, as well as a variety of physiological functions. Exposure to salinity stress manifest considerable ROS clustering, entailing modification in performance of various organelles. To deal with salinity, plants use a variety of coping strategies, such as osmoregulation, ion -homeostasis, increased antioxidant synthesis, and so on. Nitric oxide (NO) is a pivotal signalling molecule that helps facilitate salt stress-induced physiological plant responses. A variety of evidences point to NO being pro-duced under similar stress conditions and with similar kinetics as hydrogen peroxide (H2O2). The interplay between H2O2 and NO has important functional implications for modulating plant transduction processes. Be-sides, NO and calcium (Ca2+)-dependent pathways also have some connection in salt stress response mecha-nisms. Extensive crosstalk between NO and Ca2+ signalling pathways is investigated, and it suggests that almost every type of Ca2+ channel is under the tight control of NO, and NO acts as a Ca2+ mobilising compound and aids in signal reliance. The review provides insights into understanding recent advances regarding NO's, Ca2+ and H2O2 role in salt stress reduction with entwine signaling mechanisms.