Gelatin and catechol-modified quaternary chitosan cotton dressings with rapid hemostasis and high-efficiency antimicrobial capacity to manage severe bleeding wounds

被引：18

作者：

Li, Lin ^{[1
,2
]}

Chen, Dongfan ^{[1
]}

Chen, Jiale ^{[1
]}

Yang, Chao ^{[1
]}

Zeng, Youyun ^{[2
]}

Jin, Ting ^{[2
]}

Zhang, Yanmei ^{[2
]}

Sun, Xiaoyu ^{[2
]}

Mao, Hongli ^{[1
]}

Mu, Zhixiang ^{[2
]}

Shen, Xinkun ^{[3
]}

Ruan, Zhanwei ^{[3
]}

Cai, Xiaojun ^{[2
]}

机构：

[1] Nanjing Tech Univ, Coll Mat Sci & Engn, Nanjing 211816, Peoples R China

[2] Wenzhou Med Univ, Sch & Hosp Stomatol, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Ruian Peoples Hosp, Affiliated Hosp 3, Wenzhou 325016, Peoples R China

来源：

MATERIALS & DESIGN | 2023年 / 229卷

基金：

中国国家自然科学基金;

关键词：

Rapid hemostasis; Antimicrobial; Wound healing; Cotton dressing; Catechol modified quaternary chitosan; ANTIBACTERIAL; DOPAMINE; HYDROGEL; GAUZE;

D O I：

10.1016/j.matdes.2023.111927

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The development of functional wound dressings capable of both rapid hemostasis and high-efficiency antimicrobial is essential for the management of severe bleeding wounds. Cotton dressings are widely used in clinical practice; however, few dressings can simultaneously achieve rapid hemostasis and high-efficacy antimicrobial. Herein, a versatile cotton dressing (GCQCNF-5) was masterly developed by sequentially deposition catechol modified quaternary chitosan (CQCS) and gelatin onto a cotton nonwoven fabric (NF) surface. Because of the presence of a gelatin sponge layer with suitable thickness and porosity on its surface, GCQCNF-5 exhibits a notably enhanced hemostatic effect compared to NF both in vitro and in vivo, which is even slightly superior to that of MHS (a commercial gelatin hemostatic sponge). Moreover, after exerting a rapid hemostasis effect, GCQCNF-5 can further exploit CQCS to exert excellent immediate antimicrobial and long-lasting bacteriostatic effects. In vivo wound healing experiments further indicated that GCQCNF-5 could significantly promote rapid healing of infected wounds by effectively sterilizing, absorbing exudates, and providing moist healing environments. This study clearly demonstrated that GCQCNF-5 is a versatile wound dressing that can achieve simultaneously rapid hemostasis, high-efficiency antimicrobial, and promote rapid healing of infected wounds, with great application potential for the treatment of severe bleeding wounds.& COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页数：18