Mechanism and regulation of secondary immunoglobulin diversification

被引：0

作者：

Bello, Amanda ^{[1
]}

Hirth, Gianna ^{[1
]}

Voigt, Stefanie ^{[1
]}

Tepper, Sandra ^{[1
]}

Jungnickel, Berit ^{[1
,2
]}

机构：

[1] Friedrich Schiller Univ, Inst Biochem & Biophys, Fac Biol Sci, Jena, Germany

[2] Friedrich Schiller Univ Jena, Inst Biochem & Biophys, Fac Biol Sci, Dept Cell Biol, Hans Knoll Str 2, D-07745 Jena, Germany

来源：

CELL CYCLE | 2023年 / 22卷 / 18期

关键词：

Somatic hypermutation; germinal center; lymphomagenesis; INDUCED-CYTIDINE-DEAMINASE; ACTIVATION-INDUCED DEAMINASE; CLASS SWITCH RECOMBINATION; GERMINAL-CENTER FORMATION; PROTEIN-KINASE-A; B-CELL; SOMATIC HYPERMUTATION; DNA BREAKS; GENOMIC INSTABILITY; GENE CONVERSION;

D O I：

10.1080/15384101.2023.2275397

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Secondary immunoglobulin diversification by somatic hypermutation and class switch recombination in B cells is instrumental for an adequate adaptive humoral immune response. These genetic events may, however, also introduce aberrations into other cellular genes and thereby cause B cell malignancies. While the basic mechanism of somatic hypermutation and class switch recombination is now well understood, their regulation and in particular the mechanism of their specific targeting to immunoglobulin genes is still rather mysterious. In this review, we summarize the current knowledge on the mechanism and regulation of secondary immunoglobulin diversification and discuss known mechanisms of physiological targeting to immunoglobulin genes and mistargeting to other cellular genes. We summarize open questions in the field and provide an outlook on future research.

引用

页码：2070 / 2087

页数：18

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