Effects of a liquefied petroleum gas stove intervention on stillbirth, congenital anomalies and neonatal mortality: A multi-country household air pollution intervention network trial

被引：1

作者：

Younger, Ashley ^{[1
]}

Ye, Wenlu ^{[2
]}

Alkon, Abbey ^{[1
]}

Harknett, Kristen ^{[1
]}

Elon, Lisa ^{[4
]}

Diaz-Artiga, Anaite ^{[6
]}

Kirby, Miles A. ^{[3
,6
]}

Lovvorn, Amy E. ^{[5
,6
]}

Wang, Jiantong ^{[4
,6
]}

McCracken, John P. ^{[7
]}

Gonzalez, Adly Castanaza ^{[8
,9
,10
]}

Monroy, Libny ^{[8
,9
,10
]}

Mukeshimana, Alexie ^{[8
]}

Rosa, Ghislaine ^{[9
]}

Chiang, Marilu ^{[15
]}

Balakrishnan, Kalpana ^{[10
]}

Garg, Sarada S. ^{[10
]}

Pillarisetti, Ajay ^{[2
]}

Piedrahita, Ricardo ^{[11
]}

Johnson, Michael A. ^{[11
]}

Craik, Rachel ^{[12
]}

Papageorghiou, Aris T. ^{[12
]}

Toenjes, Ashley ^{[13
]}

Williams, Kendra N. ^{[15
,16
]}

Underhill, Lindsay J. ^{[13
]}

Hartinger, Stella M. ^{[14
]}

Nicolaou, Laura ^{[15
,16
]}

Chang, Howard H. ^{[4
]}

Naeher, Luke P. ^{[7
]}

Rosenthal, Joshua ^{[17
]}

Checkley, William ^{[15
,16
]}

Peel, Jennifer L. ^{[18
]}

Clasen, Thomas F. ^{[5
]}

Thompson, Lisa M. ^{[5
,19
]}

机构：

[1] Univ Calif San Francisco, Sch Nursing, San Francisco, CA USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA USA

[3] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA

[4] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA

[5] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, CA USA

[6] Univ Valle Guatemala, Ctr Hlth Studies, Guatemala City, Guatemala

[7] Univ Georgia, Coll Publ Hlth, Dept Environm Hlth Sci, Athens, GA USA

[8] Eagle Res Ctr, Kigali, Rwanda

[9] London Sch Hyg & Trop Med, Dept Dis Control, London, England

[10] Sri Ramachandra Inst Higher Educ & Res, Dept Environm Hlth Engn, ICMR Ctr Adv Res Air Qual Climate & Hlth, Chennai, India

[11] Berkeley Air Monitoring Grp, Berkeley, CA USA

[12] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford, England

[13] Washington Univ St Louis, Dept Med, Cardiovasc Div, St Louis, MO USA

[14] Univ Peruana Cayetano Heredia, Latin Amer Ctr Excellence Climate Change & Hlth, Lima, Peru

[15] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care, Baltimore, MD USA

[16] Johns Hopkins Univ, Ctr Global Noncommunicable Dis Res & Training, Sch Med, Baltimore, MD USA

[17] NIH, Fogarty Int Ctr, Div Epidemiol & Populat Studies, Bethesda, MD USA

[18] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO USA

[19] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA USA

来源：

ENVIRONMENTAL POLLUTION | 2024年 / 345卷

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

Cooking fuel; Birth outcomes; Low-and middle-income countries; Congenital anomaly; Stillbirth; Neonatal mortality; RANDOMIZED-CONTROLLED-TRIAL; OUTCOMES; FIELD;

D O I：

10.1016/j.envpol.2024.123414

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Household air pollution (HAP) from cooking with solid fuels used during pregnancy has been associated with adverse pregnancy outcomes. The Household Air Pollution Intervention Network (HAPIN) trial was a randomized controlled trial that assessed the impact of a liquefied petroleum gas (LPG) stove and fuel intervention on health in Guatemala, India, Peru, and Rwanda. Here we investigated the effects of the LPG stove and fuel intervention on stillbirth, congenital anomalies and neonatal mortality and characterized exposure -response relationships between personal exposures to fine particulate matter (PM2.5), black carbon (BC) and carbon monoxide (CO) and these outcomes. Pregnant women (18 to <35 years of age; gestation confirmed by ultrasound at 9 to <20 weeks) were randomly assigned to intervention or control arms. We monitored these fetal and neonatal outcomes and personal exposure to PM2.5, BC and CO three times during pregnancy, we conducted intention -to -treat (ITT) and exposure -response (E -R) analyses to determine if the HAPIN intervention and corresponding HAP exposure was associated with the risk of fetal/neonatal outcomes. A total of 3200 women (mean age 25.4 +/- 4.4 years, mean gestational age at randomization 15.4 +/- 3.1 weeks) were included in this analysis. Relative risks for stillbirth, congenital anomaly and neonatal mortality were 0.99 (0.60, 1.66), 0.92 (95 % CI 0.52, 1.61), and 0.99 (0.54, 1.85), respectively, among women in the intervention arm compared to controls in an ITT analysis. Higher mean personal exposures to PM2.5, CO and BC during pregnancy were associated with a higher, but statistically non -significant, incidence of adverse outcomes. The LPG stove and fuel intervention did not reduce the risk of these outcomes nor did we find evidence supporting an association between personal exposures to HAP and stillbirth, congenital anomalies and neonatal mortality.

引用

页数：11

共 18 条

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