Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD plus Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies

被引：0

作者：

Giorgetti, Giulia ^{[1
,2
]}

Becherini, Pamela ^{[2
]}

Maroto-Martin, Elena ^{[1
,3
]}

Fenoglio, Daniela ^{[4
,5
,6
]}

Soncini, Debora ^{[2
]}

Martinuzzi, Claudia ^{[4
]}

Bruzzone, Santina ^{[7
]}

Benzi, Andrea ^{[7
]}

Nahimana, Aimable ^{[8
,9
]}

Uras, Chiara Rosa Maria ^{[10
]}

Schavgoulidze, Anais ^{[1
,11
]}

Fong, Jessica Ng ^{[1
]}

Lemoli, Roberto M. ^{[12
,13
]}

Munshi, Nikhil C. ^{[1
,3
,14
]}

Fulciniti, Mariateresa ^{[1
,3
]}

Cea, Michele ^{[4
,12
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Jerome Lipper Multiple Myeloma Ctr, Boston, MA USA

[2] Univ Genoa, Dept Internal Med & Med Specialties DiMI, Clin Hematol, Genoa, Italy

[3] Harvard Med Sch, Boston, MA USA

[4] IRCCS Osped Policlin San Martino, Genoa, Italy

[5] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

[6] Univ Genoa, Dept Internal Med, Genoa, Italy

[7] Univ Genoa, Dept Expt Med DIMES, Genoa, Italy

[8] Lausanne Univ Hosp, Cent Hematol Lab, Dept Med Lab & Pathol, Lausanne, Switzerland

[9] Univ Lausanne, Lausanne, Switzerland

[10] Univ Genoa, Dept Expt Med, Ctr Excellence Biomed Res, Genoa, Italy

[11] Univ Toulouse, INSERM, UMR1037, Toulouse Canc Res Ctr Oncopole, Toulouse, France

[12] Univ Genoa, Clin Hematol, Dept Internal Med DiMI, Genoa, Italy

[13] IRCCS San Martino Hosp, Genoa, Italy

[14] VA Boston Heathcare Syst, Boston, MA USA

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-189439

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 21 条

[1] CD38 and CD45 expression on plasma cells and response to daratumumab in Multiple Myeloma
Lammers, Eline
Cuenca, Marta
Bloem, Andries
Minnema, Monique
Jak, Margot
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E164 - E164
[2] Upregulation of CD38 Expression on Multiple Myeloma Cells By the HDAC Inhibitor Ricolinostat Augments the Efficacy of Daratumumab
Garcia-Guerrero, Estefania
Danhof, Sophia
Schreder, Martin
Perez-Simon, Jose A.
Einsele, Hermann
Hudecek, Michael
BLOOD, 2017, 130
[3] DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma
Choudhry, Priya
Mariano, Margarette
Geng, Huimin
Wiita, Arun
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E144 - E145
[4] DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma
Choudhry, Priya
Mariano, Margarette C.
Wiita, Arun P.
BLOOD, 2018, 132
[5] Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Krejcik, Jakub
Frerichs, Kris A.
Nijhof, Inger S.
van Kessel, Berris
van Velzen, Jeroen F.
Bloem, Andries C.
Broekmans, Marloes E. C.
Zweegman, Sonja
van Meerloo, Johan
Musters, Rene J. P.
Poddighe, Pino J.
Groen, Richard W. J.
Chiu, Christopher
Plesner, Torben
Lokhorst, Henk M.
Sasser, A. Kate
Mutis, Tuna
van de Donk, Niels W. C. J.
CLINICAL CANCER RESEARCH, 2017, 23 (24) : 7498 - 7511
[6] DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma
Choudhry, Priya
Mariano, Margarette C.
Geng, Huimin
Martin, Thomas G., III
Wolf, Jeffrey L.
Wong, Sandy W.
Shah, Nina
Wiita, Arun P.
LEUKEMIA, 2020, 34 (03) : 938 - 941
[7] DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma
Priya Choudhry
Margarette C. Mariano
Huimin Geng
Thomas G. Martin
Jeffrey L. Wolf
Sandy W. Wong
Nina Shah
Arun P. Wiita
Leukemia, 2020, 34 : 938 - 941
[8] Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab
Nijhof, I. S.
Groen, R. W. J.
Lokhorst, H. M.
van Kessel, B.
Bloem, A. C.
van Velzen, J.
de Jong-Korlaar, R.
Yuan, H.
Noort, W. A.
Klein, S. K.
Martens, A. C. M.
Doshi, P.
Sasser, K.
Mutis, T.
van de Donk, N. W. C. J.
LEUKEMIA, 2015, 29 (10) : 2039 - 2049
[9] Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab
I S Nijhof
R W J Groen
H M Lokhorst
B van Kessel
A C Bloem
J van Velzen
R de Jong-Korlaar
H Yuan
W A Noort
S K Klein
A C M Martens
P Doshi
K Sasser
T Mutis
N W C J van de Donk
Leukemia, 2015, 29 : 2039 - 2049
[10] Modulation of CD38 Expression Levels on Multiple Myeloma Tumor Cells By All-Trans Retinoic Acid Improves the Efficacy of the Anti-CD38 Monoclonal Antibody Daratumumab
Nijhof, Inger S.
Lokhorst, Henk M.
van Kessel, Berris
Groen, Richard W. J.
Martens, Anton C.
Doshi, Parul
Klein, Saskia K.
Mutis, Tuna
Sasser, Kate
van de Donk, Niels W. C. J.
BLOOD, 2014, 124 (21)

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