USP1 inhibition induces single strand DNA gap accumulation and overcomes PARP inhibitor resistance in BRCA1 deficient cancer cells

被引:0
|
作者
da Costa, Alexandre A. B. A.
Somuncu, Ozge
Ravindranathan, Ramya
Mukkavalli, Sirisha
Martignetti, David B.
Nguyen, Huy
Jiao, Yuqing
Lamarre, Benjamin
Moreau, Lisa
Liu, Joyce
Iyer, Divya
Lazaro, Jean-Bernard
Shapiro, Geoffrey I.
Parmar, Kalindi
D'Andrea, Alan D.
机构
关键词
D O I
10.1158/1538-7445.DNAREPAIR24-B032
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B032
引用
收藏
页数:2
相关论文
共 50 条
  • [1] The USP1 inhibitor I-138 kills BRCA1-deficient tumor cells and overcomes PARP inhibitor resistance
    Da Costa, Alexandre Andre B. A.
    Bose, Arindam
    Martignetti, David
    Ayala-Zambrano, Cecilia
    Ravindranathan, Ramya
    Sadatrezaei, Golbahar
    Jiao, Yuqing
    Kochupurakkal, Bose
    Nguyen, Huy
    Lazaro, Jean-Bernard
    Parmar, Kalindi
    Shapiro, Geoffrey I.
    D'Andrea, Alan D.
    CANCER RESEARCH, 2023, 83 (07)
  • [3] Inhibition of ATR overcomes the PARP inhibitor resistance of BRCA-deficient cancer cells
    Yazinski, A.
    Zou, Lee
    CLINICAL CANCER RESEARCH, 2018, 24 (15) : 17 - 17
  • [4] The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors
    Cadzow, Louise
    Brenneman, Jehrod
    Tobin, Erica
    Sullivan, Pamela
    Nayak, Sumeet
    Ali, Janid A.
    Shenker, Sol
    Griffith, Jim
    McGuire, Michael
    Grasberger, Paula
    Mishina, Yuji
    Murray, Morgan
    Dodson, Anne E.
    Gannon, Hugh
    Krall, Elsa
    Hixon, Jeff
    Chipumuro, Edmond
    Sinkevicius, Kerstin
    Gokhale, Prafulla C.
    Ganapathy, Suthakar
    Matulonis, Ursula A.
    Liu, Joyce F.
    Olaharski, Andrew
    Sangurdekar, Dipen
    Liu, Hanlan
    Wilt, Jeremy
    Schlabach, Michael
    Stegmeier, Frank
    Wylie, Andrew A.
    CANCER RESEARCH, 2024, 84 (20) : 3419 - 3434
  • [5] Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity
    da Costa, Alexandre A.
    Somuncu, Ozge
    Ravindranathan, Ramya
    Mukkavalli, Sirisha
    Martignetti, David B.
    Nguyen, Huy
    Jiao, Yuqing
    Lamarre, Benjamin P.
    Sadatrezaei, Golbahar
    Moreau, Lisa
    Liu, Joyce
    Iyer, Divya R.
    Lazaro, Jean-Bernard
    Shapiro, Geoffrey I.
    Parmar, Kalindi
    D'Andrea, Alan D.
    CANCER RESEARCH, 2024, 84 (20) : 3435 - 3446
  • [6] Single strand DNA GAP accumulation as a functional biomarker for USP1 inhibitor sensitivity in ovarian cancer patient-derived organoid models
    Da Costa, Alexandre Andre B. A.
    Somuncu, Ozge
    Ravindranathan, Ramya
    Mukkavalli, Sirisha
    Martigneti, David
    Huy Nguyen
    Jiao, Yuqing
    Lamarre, Benjamin
    Sadatrezai, Golbahar
    Moreau, Lisa
    Liu, Joyce
    Iyer, Divya
    Lazaro, Jean-Bernard
    Shapiro, Geoffrey
    Parmar, Kalindi
    D'Andrea, Alan D.
    CANCER RESEARCH, 2024, 84 (06)
  • [7] RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance
    Wang, Yifan
    Krais, John J.
    Bernhardy, Andrea J.
    Nicolas, Emmanuelle
    Cai, Kathy Q.
    Harrell, Maria I.
    Kim, Hyoung H.
    George, Erin
    Swisher, Elizabeth M.
    Simpkins, Fiona
    Johnson, Neil
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (08): : 3145 - 3157
  • [8] Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells
    Alvarado-Cruz, Isabel
    Mahmoud, Mariam
    Khan, Mohammed
    Zhao, Shilin
    Oeck, Sebastian
    Meas, Rithy
    Clairmont, Kaylyn
    Quintana, Victoria
    Zhu, Ying
    Porciuncula, Angelo
    Wyatt, Hailey
    Ma, Shuangge
    Shyr, Yu
    Kong, Yong
    LoRusso, Patricia M.
    Laverty, Daniel
    Nagel, Zachary D.
    Schalper, Kurt A.
    Krauthammer, Michael
    Sweasy, Joann B.
    BIOCHEMICAL PHARMACOLOGY, 2021, 184
  • [9] Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance
    Tacconi, Eliana M. C.
    Badie, Sophie
    De Gregoriis, Giuliana
    Reislander, Timo
    Lai, Xianning
    Porru, Manuela
    Folio, Cecilia
    Moore, John
    Kopp, Arnaud
    Torres, Julia Baguna
    Sneddon, Deborah
    Green, Marcus
    Dedic, Simon
    Lee, Jonathan W.
    Batra, Ankita Sati
    Rueda, Oscar M.
    Bruna, Alejandra
    Leonetti, Carlo
    Caldas, Carlos
    Cornelissen, Bart
    Brino, Laurent
    Ryan, Anderson
    Biroccio, Annamaria
    Tarsounas, Madalena
    EMBO MOLECULAR MEDICINE, 2019, 11 (07)
  • [10] BRCA1 N-terminal-deficient proteins provide PARP inhibitor and platinum resistance
    Wang, Yifan
    Bernhardy, Andrea
    Nicolas, Emmanuelle
    Winters, Ryan
    Cai, Kathy
    Duncan, Kelly
    Duncan, James
    Harrell, Maria
    Swisher, Elizabeth
    Johnson, Neil
    CANCER RESEARCH, 2015, 75