Objective center dot This study aimed to investigate the effectiveness of enhanced recovery after surgery (ERAS) during the perioperative period for patients with ureteral stones. Methods center dot A total of 105 patients with ureteral stones who underwent holmium laser lithotripsy at our hospital between January 2020 and January 2021 were included in the study. They were randomly divided into two groups using a random number table: the research group (n = 53) received ERAS, while the control group (n = 52) received conventional care. Postoperative recovery parameters were compared between the two groups, including time to mobilization, time to void, time to rehydration, time to remove the urinary catheter, and length of hospital stay. Visual analogue scoring (VAS) scores were assessed at 12, 24, 36, and 48 hours postoperatively. The General Quality of Life Questionnaire (GQOLI-74) scores and complication rates were compared. Results center dot The research group exhibited significantly shorter postoperative time to mobilization, time to void, time to rehydration, time to remove the urinary catheter, and length of hospital stay compared to the control group (P <.05). VAS scores at 12, 24, 36, and 48 hours postoperatively were significantly lower in the research group than in the control group (P <.05). Furthermore, post-intervention, all GQOLI-74 scores were significantly higher in the research group than in the control group (P <.05). The complication rate in the research group was 5.66% lower than in the control group (25.00% vs. 30.66%, respectively, P <.05). Conclusions center dot The application of ERAS during the perioperative period for patients with ureteral stones is associated with improved postoperative recovery, reduced postoperative pain, lower complication rates, and enhanced quality of life. These findings suggest that ERAS is a valuable approach to be promoted for clinical use.