Urinary Electrophoretograms Performed by Capillary Electrophoresis: Comparison between Dogs and Cats

Electrophoresis of urine to evaluate different urinary proteins has been used in recent years in veterinary medicine, as it can be a useful laboratory tool in the early detection of kidney damage. However, urinary capillary electrophoresis (UCE) has not been reported in healthy cats. In healthy dogs, reference intervals have been established and can be compared with pathological samples as these provide an easily interpretable pattern. The electrophoretogram in this study is divided into five fractions (F1-F5) by serum (albumin; alpha(1)-globulin; alpha(2)-globulin; beta-globulin; and gamma-globulin). Urine samples from 14 healthy cats were obtained by eco-guided cystocentesis. UCE was run in all samples and compared to 123 dog electrophoretograms from a previously published study. Fraction 2 (alpha(1)-globulin) was statistically decreased in cats (G(1)) compared to dogs (G(2)). Fraction 4 (beta-globulin) was statistically augmented in cats compared to the canine population (G(2)). Fraction 5 (gamma-globulin) was statistically decreased in cats (G(1)) compared to dogs (G(2)). No statistical correlation was found between each cat's serum and urinary fractions. The results of the present study suggest that UCE patterns in cats are similar to the ones described in dogs. UCE can be a non-invasive new diagnostic tool in cats as pathological patterns can be compared to normal ones.