Tobacco withdrawal-induced changes in sensorimotor filtering as a predictor of smoking lapse in trauma-exposed individuals

被引：0

作者：

Pineles, Suzanne L. ^{[1
,2
,10
]}

Ni, Pengsheng ^{[3
,4
]}

Pandey, Shivani ^{[1
]}

Japuntich, Sandra J. ^{[5
,6
]}

Cesare, Nina ^{[4
]}

Shor, Rachel ^{[1
]}

Carpenter, Joseph K. ^{[1
,2
]}

Gregor, Kristin ^{[2
,7
]}

Joos, Celina M. ^{[8
]}

Blumenthal, Terry D. ^{[9
]}

Rasmusson, Ann M. ^{[1
,2
]}

机构：

[1] VA Boston Healthcare Syst, Natl Ctr PTSD, Womens Hlth Sci Div, Boston, MA 02130 USA

[2] Boston Univ, Dept Psychiat, Chobanian & Avedisian Sch Med, Boston, MA USA

[3] Boston Univ, Sch Publ Hlth, Hlth Law Policy & Management Dept, Boston, MA USA

[4] Boston Univ, Sch Publ Hlth, Biostat & Epidemiol Data Analyt Ctr, Boston, MA USA

[5] Hennepin Healthcare Res Inst, Behav Hlth Equ Res Grp, Minneapolis, MN USA

[6] Univ Minnesota, Dept Med, Med Sch, Minneapolis, MN USA

[7] VA Boston Healthcare Syst, Mental Hlth Serv, Brockton, MA 02130 USA

[8] Penn State Univ, Psychol Dept, State Coll, PA USA

[9] Wake Forest Univ, Dept Psychol, Winston Salem, NC USA

[10] VA Boston Healthcare Syst, 116B-3, Boston, MA 02130 USA

来源：

ADDICTIVE BEHAVIORS | 2024年 / 148卷

关键词：

Posttraumatic stress disorder; Prepulse inhibition; Startle; Tobacco use disorder; Smoking cessation; Contingency management; ACOUSTIC STARTLE RESPONSE; PREPULSE INHIBITION; CIGARETTE-SMOKING; VALIDATION; RECEPTORS; SMOKERS; MICE;

D O I：

10.1016/j.addbeh.2023.107868

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Prepulse inhibition (PPI) is a measure of sensorimotor filtering thought to shield the processing of initial weaker auditory stimuli from interruption by a later startle response. Previous studies have shown smoking withdrawal to have a negative impact on sensorimotor filtering, particularly in individuals with psychopathology. Because tobacco use may alleviate sensory and sensorimotor filtering deficits, we examined whether smoking withdrawal-induced changes in PPI were associated with maintenance of smoking abstinence in trauma-exposed individuals with and without PTSD who were attempting to quit smoking. Thirty-eight individuals (n = 24 with current or past PTSD; 14 trauma-exposed healthy controls) made an acute biochemically-verified smoking cessation attempt supported by 8 days of contingency management (CM) and cognitive behavioral therapy (CBT) for smoking. Participants completed a PPI task at the pre-quit baseline, 2 days post-quit, and 5 days post-quit. Post-quit changes in PPI were compared between those who remained abstinent for the first 8-days of the quit attempt and those who lapsed back to smoking. PPI changes induced by biochemically-verified smoking abstinence were associated with maintenance of abstinence across the 8-day CM/CBT-supported quit attempt. As compared to those who maintained tobacco abstinence, participants who lapsed to smoking had significantly lower PPI at 2 and 5 days post-quit relative to baseline. Thus, among trauma-exposed individuals, decreases in PPI during acute smoking cessation supported by CM/CBT are associated with lapse back to smoking. Interventions that improve PPI during early smoking abstinence may facilitate smoking cessation among such individuals who are at high risk for chronic, refractory tobacco use.

引用

页数：5