T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy

被引：2

作者：

Zebley, Caitlin C. ^{[1
]}

Youngblood, Ben ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, Memphis, TN 38105 USA

来源：

TRENDS IN IMMUNOLOGY | 2023年 / 44卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.it.2023.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Functional persistence of chimeric antigen receptor (CAR) T cells is re-quired for sustaining an antitumor response. Recently, Jain et al. re-vealed that disruption of TET2 in CAR T cells resulted in antigen -independent CAR T cell hyper-proliferation that enhanced tumor control in mice, highlighting the potential of epigenetic strategies to improve T cell-based cancer immunotherapy.

引用

页码：397 / 398

页数：2

共 50 条

[1] TET2 DISRUPTION ENHANCES THE EFFICACY OF CD19 CAR T-CELL THERAPY
不详
CANCER DISCOVERY, 2018, 8 (07) : 793 - 793
[2] TET2, tumor control, and CAR T cell hyperproliferation
Dash, Barsha
Hogan, Patrick G.
TRENDS IN CANCER, 2023, 9 (07): : 521 - 523
[3] TET2 Gene Disruption via Lentiviral Integration Promotes CAR T Cell Expansion and Persistence
Fraietta, Joseph A.
Nobles, Christopher L.
Sammons, Morgan
Lundh, Stefan
Carty, Shannon A.
Reich, Tyler
Cogdill, Alexandria P.
Wang, Yan
Gohil, Mercy
Kulikovskaya, Irina
Nazimuddin, Farzana
Gupta, Minnal
Liu, Xiaojun
Young, Regina M.
Ambrose, David E.
Jordan, Martha S.
Levine, Bruce L.
Zhao, Yangbing
Porter, David L.
Marcucci, Katherine T.
Kalos, Michael
Lacey, Simon F.
Berger, Shelly L.
Bushman, Frederic D.
June, Carl H.
Melenhorst, Jan J.
MOLECULAR THERAPY, 2017, 25 (05) : 332 - 332
[4] Implications of TET2 in CAR-T Cell Activity and Target Response to CAR-T Cell Therapy: Lessons Learned from T Cells
Pasca, Sergiu
Jurj, Ancuta
Constantinescu, Catalin
Zdrenghea, Mihnea
Tomuleasa, Ciprian
CRITICAL REVIEWS IN IMMUNOLOGY, 2021, 41 (01) : 13 - 21
[5] Biological insights into the role of TET2 in T cell lymphomas
Carty, Shannon A.
FRONTIERS IN ONCOLOGY, 2023, 13
[6] Recurrent TET2 mutations in adult T cell leukemia
Ambroise Marçais
Katia Hanssens
Lucy Cook
Thomas Mercher
Philippe Gaulard
Vahid Asnafi
Claudine Pique
Ali Bazarbachi
Felipe Suarez
Olivier Bernard
Charles RM Bangham
Patrice Dubreuil
Olivier Hermine
Retrovirology, 11 (Suppl 1)
[7] TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
Dimitri, Alexander J.
Baxter, Amy E.
Chen, Gregory M.
Hopkins, Caitlin R.
Rouin, Geoffrey T.
Huang, Hua
Kong, Weimin
Holliday, Christopher H.
Wiebking, Volker
Bartoszek, Robert
Drury, Sydney
Dalton, Katherine
Koucky, Owen M.
Chen, Zeyu
Giles, Josephine R.
Dils, Alexander T.
Jung, In-Young
O'Connor, Roddy
Collins, Sierra
Everett, John K.
Amses, Kevin
Sherrill-Mix, Scott
Chandra, Aditi
Goldman, Naomi
Vahedi, Golnaz
Jadlowsky, Julie K.
Young, Regina M.
Melenhorst, Jan Joseph
Maude, Shannon L.
Levine, Bruce L.
Frey, Noelle V.
Berger, Shelley L.
Grupp, Stephan A.
Porter, David L.
Herbst, Friederike
Porteus, Matthew H.
Carty, Shannon A.
Bushman, Frederic D.
Weber, Evan W.
Wherry, E. John
Jordan, Martha S.
Fraietta, Joseph A.
SCIENCE ADVANCES, 2024, 10 (46):
[8] TET2 guards against unchecked BATF3-induced CAR T cell expansion
Jain, Nayan
Zhao, Zeguo
Feucht, Judith
Koche, Richard
Iyer, Archana
Dobrin, Anton
Mansilla-Soto, Jorge
Yang, Julie
Zhan, Yingqian
Lopez, Michael
Gunset, Gertrude
Sadelain, Michel
NATURE, 2023, 615 (7951) : 315 - +
[9] TET2 guards against unchecked BATF3-induced CAR T cell expansion
Nayan Jain
Zeguo Zhao
Judith Feucht
Richard Koche
Archana Iyer
Anton Dobrin
Jorge Mansilla-Soto
Julie Yang
Yingqian Zhan
Michael Lopez
Gertrude Gunset
Michel Sadelain
Nature, 2023, 615 : 315 - 322
[10] TET2 and TET3 regulate helper T cell differentiation in the periphery
Nakatsukasa, Hiroko
Yoshimura, Akihiko
CYTOKINE, 2017, 100 : 172 - 172

← 1 2 3 4 5 →