Evaluation the possible Genotoxic Effect of Vitex Negundo Ethyl Acetate Fraction on Chromosomal Aberration in Mouse Spleen and Bone Marrow Cell

Chromosome aberrations have long been recognized to be an important biomarker of human exposure to ionising radiation and genotoxic chemicals .many of plant in nature use for treatment of many diseases The present study is designed to evaluate the possible genotoxic effect of ethyl acetate fraction of vitex negundo (verbenaceae)on chromosomal integrity at two different doses (100mg/kg and 200mg/kg) on both bone marrow cells and spleen cells in mice for seven successive days, the results was compare their effects with methotrexate which was used as a positive control. The results have been showed that ethyl acetate fraction of vitex negundo at both doses showed a significant decrease in individual and total chromosomal aberration when compared with negative control (dimethylsulfoxide).