Recent development of polymer nanomicelles in the treatment of eye diseases

被引:9
|
作者
Cai, Ruijun [1 ]
Zhang, Ling [1 ]
Chi, Hao [2 ]
机构
[1] Peoples Hosp Jiuquan, Dept Pharm, Jiuquan, Gansu, Peoples R China
[2] Univ Hlth & Rehabil Sci, Qingdao Municipal Hosp, Qingdao, Peoples R China
关键词
eye diseases; polymer nanomicelles; treatment; drugs; biological barriers; TOPICAL OCULAR DELIVERY; BINARY MIXED MICELLES; DRUG-DELIVERY; IN-VITRO; CYCLOSPORINE-A; SMART POLYMERS; EX-VIVO; RELEASE; NANOPARTICLES; FORMULATION;
D O I
10.3389/fbioe.2023.1246974
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the development of a nano-delivery platform based on polymeric micelles. These advancements encompass diverse innovations such as poloxamer, chitosan, hydrogel-encapsulated micelles, and contact lenses embedded with micelles. Such technological evolutions allow for sustained medication retention and facilitate enhanced permeation within the eye, thereby standing as the avant-garde in ocular medication technology. This review provides a comprehensive consolidation of ocular medications predicated on polymer nanomicelles from 2014 to 2023. Additionally, it explores the challenges they pose in clinical applications, a discussion intended to aid the design of future clinical research concerning ocular medication delivery formulations.
引用
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页数:18
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