Eight-channel SiNx microring-resonator based photonic biosensor for label-free fluid analysis in the optical C-band

被引：2

作者：

Reck, Jakob ^{[1
]}

Kleinert, Moritz ^{[1
]}

Mihov, Klara ^{[1
]}

Kresse, Martin ^{[1
]}

Yilmaz, Cafercan ^{[1
]}

Hoffiiiann, Christina ^{[2
]}

Hoffiliann, Peter ^{[2
]}

Froese, Vera ^{[3
]}

Kertzscher, Ulrich ^{[3
]}

Mykhailiuk, Kristina ^{[5
]}

Michaelis, Julia ^{[5
]}

Weigel, Wilfried ^{[5
]}

Scholand, Soren ^{[6
]}

Heupke, Hans-Jurgen ^{[6
]}

Weigel, Madeleine ^{[1
]}

de Felipe, David ^{[1
]}

Qian, Tianwen ^{[1
]}

Conradi, Hauke ^{[1
]}

Zawadzki, Crispin ^{[1
]}

Keil, Norbert ^{[1
]}

Schell, Martin ^{[1
,4
]}

机构：

[1] Fraunhofer Inst Telecommun, Heinrich Hertz Inst, Photon Components Dept, Berlin, Germany

[2] Charite Univ Med Berlin, Inst Diagnost Lab Med Clin Chem & Pathobiochem, Berlin, Germany

[3] Charite Univ Med Berlin, Inst Comp Assisted Cardiovasc Med, Biofluid Mech Lab, Berlin, Germany

[4] Tech Univ Berlin, Berlin, Germany

[5] SCIENION GmbH, Berlin, Germany

[6] ESCHWEILER GmbH & CO KG, Kiel, Germany

来源：

2023 45TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY, EMBC | 2023年

关键词：

D O I：

10.1109/EMBC40787.2023.10340677

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

A lab-on-a-chip multichannel sensing platform for biomedical analysis based on optical silicon nitride (SiNx) microring-resonators (MRR) was established. The resonators were surface functionalized and finally combined with a microfluidic chamber for validation using an avidin-biotin ligand-binding assay. The results with a limit of detection ( LOD) of 2.3.10(-5) and a mean intra-assay coefficient of variation (CV) of +/- 10.0 %, also under consideration of FDA guidelines, show promising future applicability for a wide variety of targets in the field of outpatient medical diagnostics and life science.

引用

页数：4

共 25 条

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