P2X7-dependent immune pathways in retinal diseases

被引：7

作者：

Dechelle-Marquet, Paul-Alexandre ^{[1
]}

Guillonneau, Xavier ^{[1
]}

Sennlaub, Florian ^{[1
]}

Delarasse, Cecile ^{[1
]}

机构：

[1] Sorbonne Univ, Inst Vis, INSERM, CNRS, 17 Rue Moreau, F-75012 Paris, France

来源：

NEUROPHARMACOLOGY | 2023年 / 223卷

关键词：

Retina; Age-related macular degeneration; Uveitis; Macrophage; Microglia; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PURINERGIC P2X7 RECEPTOR; EXTRACELLULAR ATP; NLRP3; INFLAMMASOME; P2X(7); RELEASE; CELLS; MICROGLIA; ACTIVATION; PHAGOCYTES;

D O I：

10.1016/j.neuropharm.2022.109332

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenosine triphosphate (ATP) is a signalling molecule acting as a neurotransmitter but also as a danger signal. The purinergic receptor P2X7 is the main sensor of high concentration of ATP released by damaged cells. In the eye, P2X7 is expressed by resident microglia and immune cells that infiltrate the retina in disease such as age -related macular degeneration (AMD), a degenerative retinal disease, and uveitis, an inflammatory eye disease. Activation of P2X7 is involved in several physiological and pathological processes: phagocytosis, activation of the inflammasome NLRP3, release of pro-inflammatory mediators and cell death. The aim of this review is to discuss the potential involvement of P2X7 in the development of AMD and uveitis.

引用

页数：5

共 50 条

[1] Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages
Kawano, Ayurni
Tsukimoto, Mitsutoshi
Mori, Daisuke
Noguchi, Taisei
Harada, Hitoshi
Takenouchi, Takato
Kitani, Hiroshi
Kojima, Shuji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 420 (01) : 102 - 107
[2] NTPDase1 governs P2X7-dependent functions in murine macrophages
Levesque, Sebastien A.
Kukulski, Filip
Enjyoji, Keiichi
Robson, Simon C.
Sevigny, Jean
EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (05) : 1473 - 1485
[3] A P2X7-dependent process mediates the formation of multinucleated macrophages by GM-CSF
Lemaire, Irma
Falzoni, Simonetta
Zhang, Bin
Francesco, Di Virgilio
PURINERGIC SIGNALLING, 2008, 4 : S62 - S63
[4] Porphyromonas gingivalis Fimbriae Dampen P2X7-Dependent Interleukin-1β Secretion
Morandini, Ana Carolina
Ramos-Junior, Erivan S.
Potempa, Jan
Ky-Anh Nguyen
Oliveira, Ana Carolina
Bellio, Maria
Ojcius, David M.
Scharfstein, Julio
Coutinho-Silva, Robson
JOURNAL OF INNATE IMMUNITY, 2014, 6 (06) : 831 - 845
[5] Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages
Kshitija Dhuna
Ray Helliwell
Simone N. De Luca
Sarah J. Spencer
Leanne Stokes
Purinergic Signalling, 2024, 20 : 65 - 71
[6] P2X7-Dependent Release of Interleukin-1β and Nociception in the Spinal Cord following Lipopolysaccharide
Clark, Anna K.
Staniland, Amelia A.
Marchand, Fabien
Kaan, Timothy K. Y.
McMahon, Stephen B.
Malcangio, Marzia
JOURNAL OF NEUROSCIENCE, 2010, 30 (02): : 573 - 582
[7] 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways
Olivier, Elodie
Dutot, Melody
Regazzetti, Anne
Laprevote, Olivier
Rat, Patrice
CHEMISTRY AND PHYSICS OF LIPIDS, 2017, 207 : 171 - 178
[8] Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages
Dhuna, Kshitija
Helliwell, Ray
De Luca, Simone N.
Spencer, Sarah J.
Stokes, Leanne
PURINERGIC SIGNALLING, 2024, 20 (01) : 65 - 71
[9] Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms
Ward, Jon R.
West, Peter W.
Ariaans, Mark P.
Parker, Lisa C.
Francis, Sheila E.
Crossman, David C.
Sabroe, Ian
Wilson, Heather L.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (30) : 23145 - 23156
[10] Extracellular ATP induces IL-1beta secretion and formation of filopodia in myeloid lineage cells through distinct P2X7-dependent pathways
Thomas, Louis Michael
Chu, Jessica
Watkins, Simon C.
Stolz, Donna
Salter, Russell D.
FASEB JOURNAL, 2008, 22

← 1 2 3 4 5 →