EVIDENCE OF PAKISTANI TRADITIONAL MEDICINAL PLANTS IN PRECLINICAL AND CLINICAL STUDIES

Since the outbreak of the coronavirus problem in 2019, millions of fatalities have occurred worldwide. Till todate, absenteeism of SARS-CoV-2 specific medication is severe reality. Urge to overcome COVID-19 epidemic need an identification of all possible therapeutic targets. This can be attainable by turning cornerstone towards traditional medicinal plants (TMPs), already used for management of other fetal diseases. Pakistani TMPs/ bioactive compounds evaluated for their efficacy assessment/safety profile against COVID-19 pathogenesis, manifestation and complications via preclinical and clinical data from authentic sources. Executed investigations on effectiveness of TMPs are classified as antiviral, antiinflammatory/ Immune-dilatory in COVID -19 patients and inhibitor of structural, nonstructural proteins (RdRp and the viral proteases such as papain-like protease /PLpro and main protease /Mpro) and human inflammatory proteins in molecular docking analysis. Docking scores exhibited their inhibitory potential against entry and replication of SARS-CoV-2. Molecular Mechanics energy combined with Generalized Born and Surface Area continuation salvation method (MM/GBSA) confirmed highest receptor-ligand (TMPs/Bioactive compounds and protein/enzymes of coronavirus) affinity with high stability profile. Accomplishment of successful clinical trials on TPMs, proved their competence to interfere with COVID-19 manifestations. This article provides up-to-date effectiveness/safety profile particulars TMPs/Bioactive compounds, as adjunctive treatment and supportive therapy in SARS-CoV-2 due enough level of evidence, via preclinical and clinical data.