Palladium-Catalyzed Stereoselective Defluorosilylation of gem-Difluoroalkenes for the Synthesis of Tetrasubstituted Monofluorinated Vinylsilanes

被引：0
|
作者：
Tsui, Gavin Chit [1 ]
Zong, Yuwei [1 ]
Luo, Ziwei [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 13期
关键词：
SILYLATION; HALIDES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective synthesis of tetrasubstituted vinylsilanes is a challenging task. We herein report a novel palladium(0)-catalyzed defluorosilylation of fi,fi-difluoroacrylates to access tetrasubstituted vinylsilanes containing the monofluoroalkene motif in excellent diastereoselectivities (>99:1). This is our first example of C??? heteroatom bond formation from the C???F bond under such a Pd catalytic manifold.
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页码：2333 / 2337
页数：5
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