Photoinduced Minisci Reaction with Diazines: An Approach Toward Original Fused Heterocycles.

被引：4

作者：

Auvray, Marie ^{[1
]}

Jeanty, Matthieu ^{[2
]}

Jubault, Philippe ^{[1
]}

Poisson, Thomas ^{[1
]}

机构：

[1] Normandie Univ, NSA Rouen, UNIROUEN, CNRS,COBRA UMR 6014, F-76000 Rouen, France

[2] NovAliX, Campus Maigremont BP615, F-27106 Val De Reuil, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 43期

关键词：

Minisci Reaction; Photocatalysis; Heterocycles; Diazines; Continuous Flow; C-H ALKYLATION; NUCLEOPHILIC CHARACTER; SELECTIVE ALKYLATION; HETEROARENES; FUNCTIONALIZATION; RADICALS; PYRIDINE; ACIDS;

D O I：

10.1002/chem.202301417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we developed a photoinduced Minisci reaction on a large panel of diazines with good to excellent yields (28 examples, 44 % to 89 %). The reaction using 4CzIPN (1 mol %) as photoinitiator was carried out under white LED irradiation and required a slight excess of the acid reagent (1.2 equiv.). Cyclization reactions were then developed to access original N-heterocycles building blocks for drug discovery programs. An extension of the reaction to continuous flow was also reported. Finally, the mechanism of the transformation was studied suggesting a plausible radical chain mechanism.

引用

页数：6

共 8 条

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