Tissue-specific antioxidative response and metabolism of paralytic shellfish toxins in scallop (Chlamys farreri) mantle with Alexandrium dinoflagellate exposure

被引：0

作者：

Li, Moli ^{[1
,2
,3
]}

Cheng, Jie ^{[1
,2
,4
]}

Wang, Huizhen ^{[1
]}

Shi, Jiaoxia ^{[1
]}

Xun, Xiaogang ^{[1
]}

Wang, Yangrui ^{[1
]}

Lu, Wei ^{[1
]}

Hu, Jingjie ^{[1
,4
]}

Bao, Zhenmin ^{[1
,2
,4
]}

Hu, Xiaoli ^{[1
,2
]}

机构：

[1] Ocean Univ China, Key Lab Marine Genet & Breeding, Minist Educ, 5 Yushan Rd, Qingdao 266003, Peoples R China

[2] Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, 1 Wenhai Rd, Qingdao 266237, Peoples R China

[3] China Agr Univ, Coll Vet Med, Natl Key Lab Vet Publ Hlth Secur, Beijing 100193, Peoples R China

[4] Ocean Univ China, Sanya Oceanog Inst, Key Lab Trop Aquat Germplasm Hainan Prov, Sanya 572024, Peoples R China

来源：

MARINE POLLUTION BULLETIN | 2024年 / 198卷

基金：

中国国家自然科学基金;

关键词：

Bivalve; Alexandrium; Co-expression network; Xenobiotic metabolism; PSTs biomarker; PATINOPECTEN-YESSOENSIS; SAXITOXIN; CLAMS;

D O I：

10.1016/j.marpolbul.2023.115854

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bivalves show remarkable capacity to acclimate paralytic shellfish toxins (PSTs) produced by dinoflagellates, severely affecting fishery industry and public health. Here, transcriptomic response to PSTs-producing dinoflagellate (Alexandrium minutum) was investigated in Zhikong scallop (Chlamys farreri) mantle. The PSTs accumulated in C. farreri mantle continually increased during the 15 days exposure, with "oxidation-reduction" genes induced compared to the control group at the 1st and 15th day. Through gene co-expression network analysis, 16 PSTs-responsive modules were enriched with up-or down-regulated genes. The concentration of GTXs, major PSTs in A. minutum and accumulated in scallops, was correlated with the up-regulated magenta module, enriching peroxisome genes as the potential mantle-specific PSTs biomarker. Moreover, Hsp70B2s were inhibited throughout the exposure, which together with the expanded neurotransmitter transporter SLC6As, may play essential roles on neurotransmitter homeostasis in scallop mantle. These results paved the way for a comprehensive understanding of defensive mechanism and homeostatic response in scallop mantle against PSTs.

引用

页数：11

共 5 条

[1] Dynamics of paralytic shellfish toxins and their metabolites during timecourse exposure of scallops Chlamys farreri and mussels Mytilus galloprovincialis to Alexandrium pacificum
Qiu, Jiangbing
Meng, Fanping
Ding, Ling
Che, Yijia
McCarron, Pearse
Beach, Daniel G.
Li, Aifeng
AQUATIC TOXICOLOGY, 2018, 200 : 233 - 240
[2] HSP70 GENES IN THE GENOME OF ZHIKONG SCALLOP (CHLAMYS FARRERI) AND THEIR EXPRESSION REGULATION AFTER EXPOSURE TO THE DINOFLAGELLATE ALEXANDRIUM MINUTUM
Li, Xu
Xun, Xiaogang
Hu, Boyang
Li, Moli
Hu, Xiaoli
Bao, Zhenmin
TOXICON, 2019, 158 : S60 - S61
[3] Inhibition of egg hatching success and larvae survival of the scallop, Chlamys farreri, associated with exposure to cells and cell fragments of the dinoflagellate Alexandrium tamarense
Yan, T
Zhou, MJ
Fu, M
Wang, YF
Yu, RC
Li, J
TOXICON, 2001, 39 (08) : 1239 - 1244
[4] Accumulation of paralytic shellfish toxins in the scallop Patinopecten yessoensis caused by the dinoflagellate Alexandrium catenella in Otsuchi Bay, Iwate Prefecture, northern Pacific coast of Japan
Sekiguchi, K
Ogata, T
Kaga, S
Yoshida, M
Fukuyo, Y
Kodama, M
FISHERIES SCIENCE, 2001, 67 (06) : 1157 - 1162
[5] Biochemical response and tissue-specific accumulation of scallop Aequipecten tehuelchus from Patagonia, Argentina after exposure to inorganic arsenic
Sturla Lompré, Julieta
Malanga, Gabriela
Gil, Mónica Noemí
Giarratano, Erica
Chemosphere, 2024, 349

← 1 →