Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC

被引:0
|
作者
Shah, Pooja A.
Mazumdar, Tuhina
Powell, Reid T.
Shen, Li
Wang, Jing
Stephen, Clifford C.
Frederick, Mitchell J.
Johnson, Faye M.
机构
关键词
D O I
10.1158/1538-7445.AM2023-2847
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2847
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Adaptive and acquired mechanisms of resistance to PI3K inhibitors
    Chandarlapaty, Sarat
    Scaltriti, Maurizio
    Will, Marie
    Li, Zhiqiang
    Bosch-Campos, Ana
    Schwartz, Sarit
    Rodrik-Outmezguine, Vanessa
    Berger, Michael
    Jose, Baselga
    Rosen, Neal
    CANCER RESEARCH, 2015, 75
  • [2] Combination of PLK1 and PI3K inhibitors shows strong synergy in anaplastic thyroid cancer
    Yilmaz, Emrullah
    Orlacchio, Arturo
    Di Cristofano, Antonio
    CANCER RESEARCH, 2016, 76
  • [3] Synergistic effect of combined PI3K and PLK1 inhibition in anaplastic thyroid carcinoma cells.
    Yilmaz, Emrullah
    Champa, Devora
    Di Cristofano, Antonio
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [4] Targeting PI3K and PLK1 to Overcome Ibrutinib-Venetoclax Resistance in Mantle Cell Lymphoma
    Jiang, Changying
    Zhang, Rongjia
    Zhang, Shaojun
    Lee, William
    Huang, Shengjian
    Liu, Yang
    Leeming, Angela
    McIntosh, Joseph Mitchell
    Jain, Preetesh
    Nomie, Krystle
    Wang, Linghua
    Wang, Michael L.
    BLOOD, 2019, 134
  • [5] PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition
    Castel, Pau
    Ellis, Haley
    Bago, Ruzica
    Toska, Eneda
    Srinivasaraghavan, Kannan
    Carmona, F. Javier
    Razavi, Pedram
    Verma, Chandra
    Dickler, Maura
    Chandarlapaty, Sarat
    Brogi, Edi
    Alessi, Dario
    Baselga, Jose
    Scaltriti, Maurizio
    CANCER RESEARCH, 2016, 76
  • [6] Efficacy of PI3K inhibitors to PI3K mutants in enzyme and cell levels
    Dan, Shingo
    Sugita, Hironobu
    Yamazaki, Kanami
    Yamori, Takao
    CANCER RESEARCH, 2009, 69
  • [7] Imidazopyridazine Inhibitors of PI3Kβ
    Rosse, Gerard
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (12): : 1012 - 1013
  • [8] Determinants of acquired resistance to combination treatment with MEK and PI3K inhibitors
    Bhattacharya, Bhaskar
    Low, Sarah
    Chia, Dilys
    Koh, King Xin
    Chong, Mei Ling
    Benoukraf, Touati
    Soong, Richie
    CLINICAL CANCER RESEARCH, 2015, 21
  • [9] PI3K inhibition in preclinical models of HNSCC
    Hedberg, Matthew Louis
    Li, Hua
    Zeng, Yan
    Grandis, Jennifer Rubin
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (07)
  • [10] FGFR1 DRIVES RESISTANCE TO PI3K INHIBITORS VIA UP-REGULATION OF AURORA A/PLK1/CDK1 AXIS IN GLIOBLASTOMA
    Li, Xiaolong
    Zhang, Chen
    Martinez-Ledesma, Emmanuel
    Gao, Feng
    Yung, W. K. Alfred
    Koul, Dimpy
    NEURO-ONCOLOGY, 2017, 19 : 64 - 64