Pancreatic gene therapy durably improves glycaemia and delays disease progression in a murine model of type 2 diabetes

被引:0
|
作者
Rajagopalan, H. [1 ]
Lubaczeuski, C. [1 ]
Cozzi, E. [1 ]
Picard, N. [1 ]
Wainer, J. [1 ]
Reese, R. [1 ]
Caplan, J. [1 ]
West, J. [1 ]
Liou, A. P. [1 ]
机构
[1] Fractyl Hlth Inc, Lexington, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
100
引用
收藏
页码:S54 / S55
页数:2
相关论文
共 50 条
  • [1] Pancreatic Gene Therapy Durably Improves Glycemia and Delays Disease Progression in a Murine Model of Type 2 Diabetes
    Fitzpatrick, Alice L.
    Cozzi, Emily
    Wainer, Jacob
    Reese, Rebecca
    Khanna, Nidhi
    Caplan, Jay
    Rajagopalan, Harith
    West, Jason A.
    DIABETES, 2023, 72
  • [2] Single-dose GLP-1-based pancreatic gene therapy durably maintains body composition and glycaemia after semaglutide withdrawal in a murine model of obesity
    Fitzpatrick, A. L.
    Wang, S.
    Reese, R.
    Picard, N.
    Cozzi, E.
    Kieffer, T.
    Caplan, J.
    Rajagopalan, H.
    DIABETOLOGIA, 2024, 67 : S70 - S71
  • [3] Gene Expression Changes during the Progression of Diabetic Neuropathy in a Murine Model of Type 2 Diabetes
    Park, Meeyoung
    Hinder, Lucy M.
    Murdock, Ben
    Bender, Diane
    O'Brien, Phillipe
    Feldman, Eva L.
    DIABETES, 2016, 65 : A1 - A1
  • [4] SITAGLIPTIN DELAYS PROGRESSION OF RENAL LESIONS IN A RODENT MODEL OF TYPE 2 DIABETES
    Mega, C.
    Vala, H.
    Oliveira, J.
    Fernandes, R.
    Teixeira, F.
    Teixeira de Lemos, E.
    Reis, F.
    JOURNAL OF COMPARATIVE PATHOLOGY, 2013, 148 (01) : 100 - 100
  • [5] Sitagliptin treatment delays the progression of pancreatic and renal lesions and reduces tissular oxidative stress in a type 2 diabetes animal model
    Mega, C.
    Vala, H.
    Oliveira, J.
    Fernandes, R.
    Mascarenhas-Melo, F.
    Parada, B. P.
    Pinto, R. P.
    Teixeira, F.
    Reis, F.
    Teixeira de Lemos, E.
    VIRCHOWS ARCHIV, 2012, 461 : S101 - S102
  • [6] A Pancreatic Gene Therapy Delivery Platform for the Treatment of Type 2 Diabetes
    West, Jason A.
    Wainer, Jacob
    Liou, Alice
    Reese, Rebecca
    Khanna, Nidhi
    Wang, Suya
    Ishida, Keiko
    Picard, Nicole
    Lubaczeuski, Camila
    Thompson, Christopher C.
    Lee, Linda S.
    Trasolini, Roberto
    Cozzi, Emily
    Caplan, Jay
    Rajagopalan, Harith
    MOLECULAR THERAPY, 2023, 31 (04) : 103 - 103
  • [7] Therapy and clinical trials: glycaemia and prevention of macroangiopathy in type 2 diabetes
    Bolusani, Hernanth
    Peter, R.
    Rees, A.
    CURRENT OPINION IN LIPIDOLOGY, 2008, 19 (06) : 629 - 630
  • [8] Antiangiogenic gene therapy delays growth of murine and human pancreatic adenocarcinoma in mice
    Tseng, JF
    Farnebo, FA
    Kisker, O
    Becker, CM
    Kuo, CJ
    Folkman, J
    Mulligan, RC
    GASTROENTEROLOGY, 2001, 120 (05) : A349 - A349
  • [9] BMP4 gene therapy delays diabetes progression in the diabetic db/db mouse model
    Shahidi, R. Khatib
    Holm, L. Manneras
    Bonnet, L.
    Kroon, T.
    Nilsson, D.
    Ahnmark, A.
    Elias, I.
    Bosch, F.
    Smith, U.
    Boucher, J.
    DIABETOLOGIA, 2019, 62 : S122 - S122
  • [10] Rosiglitazone improves postprandial glycaemia and markers of endothelial function in patients with Type 2 diabetes
    Agrawal, A
    Chen, H
    Yan, Y
    Mather, R
    Albertini, JP
    Valensi, P
    Hanefeld, M
    DIABETOLOGIA, 2002, 45 : A251 - A251