A biocompatible adenine-based metal-organic framework for Ca2+responsive drug delivery

被引：0

作者：

Jing, Peng ^{[1
]}

Wu, Manni ^{[1
]}

Su, Jia ^{[1
]}

Zhang, Ling ^{[2
]}

Cao, Xianying ^{[3
]}

Jiang, Ke ^{[1
]}

机构：

[1] Hainan Univ, Sch Food Sci & Engn, Key Lab Food Nutr & Funct Food Hainan Prov, Haikou 570228, Peoples R China

[2] Hainan Univ, Sch Mat Sci & Engn, Haikou 570228, Peoples R China

[3] Engn Technol Res Ctr Elderly Hlth Management Haina, Haikou 571137, Peoples R China

来源：

MATERIALS LETTERS | 2023年 / 349卷

基金：

中国国家自然科学基金;

关键词：

Metal-organic framework; Ca 2+responsive drug delivery; Good biocompatibility;

D O I：

10.1016/j.matlet.2023.134812

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An anionic zinc-adeninate MOF ZJU-64-NH2 has been successfully fabricated by solvothermal method. The high crystallinity of ZJU-64-NH2 was confirmed through powder X-ray diffraction (PXRD) analysis. The cationic model drug procainamide (PA) was efficiently encapsulated into ZJU-64-NH2 through electrostatic interaction, and its loading capacity was determined to be 12.97 wt%. The drug delivery system PA@ZJU-64-NH2 exhibited Ca2+-triggered drug release due to ion exchange, indicating promising potential for bone tumor therapy. The excellent biocompatibility of ZJU-64-NH2 was demonstrated through MTT assay and confocal microscopy imaging.

引用

页数：3

共 50 条

[1] A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery
Jiang, Ke
Zhang, Ling
Hu, Quan
Yang, Yanyu
Lin, Wenxin
Cui, Yuanjing
Yang, Yu
Qian, Guodong
MATERIALS LETTERS, 2018, 225 : 142 - 144
[2] Drug Release Properties of a Series of Adenine-Based Metal-Organic Frameworks
Oh, Hyojae
Li, Tao
An, Jihyun
CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (47) : 17010 - 17015
[3] An Adenine-Based Biological Metal-Organic Framework as an Efficient Luminescent Sensor for Tetracycline Detection
Wu, Xia
Xiong, Xiao
Li, Jia-Li
Luo, Dong
Wu, Kun
Wei, Yu-Bai
Liu, Xin-Yi
Lu, Weigang
Li, Dan
He, Jian
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2022, 2022 (23)
[4] A Biocompatible Zinc(II)-based Metal-organic Framework for pH Responsive Drug Delivery and Anti-Lung Cancer Activity
Cai, Yong
Sheng, Zhaoying
Wang, Jiying
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2018, 644 (16): : 877 - 882
[5] Mild and large-scale synthesis of nanoscale metal-organic framework used as a potential adenine-based drug nanocarrier
Trang Thi Thu Nguyen
Linh Ho Thuy Nguyen
Ngoc Xuan Dat Mai
Hanh Kieu Thi Ta
Thi Lien Thuong Nguyen
Uyen-Chi Nguyen Le
Bach Thang Phan
Nhuan Ngoc Doan
Tan Le Hoang Doan
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 61
[6] Designed metal-organic framework based on metal-organic polyhedron: Drug delivery
Wu, Jian
Xu, Jing-Wen
Liu, Wei-Cong
Yang, Su-Zhen
Luo, Miao-Miao
Han, Yao-Yao
Liu, Jian-Qiang
Batten, Stuart R.
INORGANIC CHEMISTRY COMMUNICATIONS, 2016, 71 : 32 - 34
[7] Ultrasensitive and highly selective detection of formaldehyde via an adenine-based biological metal-organic framework
Wei, Yu-Bai
Wang, Ming-Jie
Luo, Dong
Huang, Yong-Liang
Xie, Mo
Lu, Weigang
Shu, Xugang
Li, Dan
MATERIALS CHEMISTRY FRONTIERS, 2021, 5 (05) : 2416 - 2424
[8] A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier
Lin, Wenxin
Cui, Yuanjing
Yang, Yu
Hu, Quan
Qian, Guodong
DALTON TRANSACTIONS, 2018, 47 (44) : 15882 - 15887
[9] Metal-Organic Framework (MOF)-Based Drug Delivery
Cao, Jian
Li, Xuejiao
Tian, Hongqi
CURRENT MEDICINAL CHEMISTRY, 2020, 27 (35) : 5949 - 5969
[10] CO2 selectivity of a 1D microporous adenine-based metal-organic framework synthesised in water
Stylianou, Kyriakos C.
Warren, John E.
Chong, Samantha Y.
Rabone, Jeremy
Bacsa, John
Bradshaw, Darren
Rosseinsky, Matthew J.
CHEMICAL COMMUNICATIONS, 2011, 47 (12) : 3389 - 3391

← 1 2 3 4 5 →